Population structure of the Yersinia pseudotuberculosis complex according to multilocus sequence typing

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Laukkanen-Ninios, Riikka ^[1] ; Didelot, Xavier ^[2] ; Jolley, Keith A. ^[3] ; Morelli, Giovanna ^[4] ; Sangal, Vartul ^[4] ; Kristo, Paula ^[5] ; Brehony, Carina ^[3] ; Imori, Priscilla F. M. ^[6] ; Fukushima, Hiroshi ^[7] ; Siitonen, Anja ^[8] ; Tseneva, Galina ^[9] ; Voskressenskaya, Ekaterina ^[9] ; Falcao, Juliana P. ^[6] ; Korkeala, Hannu ^[1] ; Maiden, Martin C. J. ^[3] ; Mazzoni, Camila ^[10] ; Carniel, Elisabeth ^[11] ; Skurnik, Mikael ^{[12, 13]} ; Achtman, Mark ^[10]

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^[1] Univ Helsinki, Dept Food Hyg & Environm Hlth, Fac Vet Med, FI-00014 Helsinki - Finland

^[2] Univ Oxford, Dept Stat, Oxford OX1 3TG - England

^[3] Univ Oxford, Dept Zool, Oxford OX1 3PS - England

^[4] Max Planck Inst Infekt Biol, D-10117 Berlin - Germany

^[5] Univ Helsinki, Haartman Inst, Sequencing Core Facil, FI-00014 Helsinki - Finland

^[6] Univ Sao Paulo, Fac Pharmaceut Sci Ribeirao Preto, Dept Clin Toxicol & Bromatol Anal, BR-05508 Sao Paulo - Brazil

^[7] Shimane Prefectural Inst Publ Hlth & Environm Sci, Matsue, Shimane 6990122 - Japan

^[8] Natl Inst Hlth & Welf THL, Bacteriol Unit, FI-00271 Helsinki - Finland

^[9] Inst Pasteur, St Petersburg - Russia

^[10] Natl Univ Ireland Univ Coll Cork, Environm Res Inst, Cork - Ireland

^[11] Inst Pasteur, Yersinia Res Unit, Yersinia Natl Reference Lab, Paris - France

^[12] Univ Helsinki, Dept Bacteriol & Immunol, Haartman Inst, FI-00014 Helsinki - Finland

^[13] Univ Helsinki, Cent Hosp, Diagnost Lab, FI-00014 Helsinki - Finland

• Tipo de documento: Artigo Científico
• Fonte: ENVIRONMENTAL MICROBIOLOGY; v. 13, n. 12, p. 3114-3127, DEC 2011.
• Citações Web of Science: 45

Resumo

Multilocus sequence analysis of 417 strains of Yersinia pseudotuberculosis revealed that it is a complex of four populations, three of which have been previously assigned species status {[}Y. pseudotuberculosis sensu stricto (s.s.), Yersinia pestis and Yersinia similis] and a fourth population, which we refer to as the Korean group, which may be in the process of speciation. We detected clear signs of recombination within Y. pseudotuberculosis s.s. as well as imports from Y. similis and the Korean group. The sources of genetic diversification within Y. pseudotuberculosis s.s. were approximately equally divided between recombination and mutation, whereas recombination has not yet been demonstrated in Y. pestis, which is also much more genetically monomorphic than is Y. pseudotuberculosis s.s. Most Y. pseudotuberculosis s.s. belong to a diffuse group of sequence types lacking clear population structure, although this species contains a melibiose-negative clade that is present globally in domesticated animals. Yersinia similis corresponds to the previously identified Y. pseudotuberculosis genetic type G4, which is probably not pathogenic because it lacks the virulence factors that are typical for Y. pseudotuberculosis s.s. In contrast, Y. pseudotuberculosis s.s., the Korean group and Y. pestis can all cause disease in humans. (AU)

• Processo FAPESP: 06/51434-7 - Rastreamento epidemiológico de amostras de Yersinia enterocolitica biotipo 1A de origens diversas e classificação de amostras de Yersinia sp. que não se enquadram bioquimicamente nas espécies conhecidas, com o auxílio técnicas fenotípicas e moleculares
• Beneficiário: Juliana Pfrimer Falcão
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 07/07784-6 - Tipagem molecular de linhagens de Yersinia pseudotuberculosis por seqüenciamento de multilocus
• Beneficiário: Priscilla Fernanda Martins Imori
• Modalidade de apoio: Bolsas no Brasil - Iniciação Científica