Paternal treatment with cisplatin impairs reproduction of adult male offspring in rats

Autor(es)

Alves Favareto, Ana Paula ^[1] ; de Toledo, Fabiola Choqueta ^[2] ; Kempinas, Wilma De Grava ^[2]

Afiliação do(s) autor(es)

^[1] State Univ Campinas UNICAMP, Program Cellular & Struct Biol, Campinas, SP - Brazil

^[2] Univ Estadual Paulista, UNESP, Inst Biociencias, Dept Morfol, BR-18618970 Botucatu, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REPRODUCTIVE TOXICOLOGY; v. 32, n. 4, p. 425-433, DEC 2011.
• Citações Web of Science: 14

Resumo

This study evaluated the acute and persistent effects of paternal cisplatin-treatment on progeny. Wistar male rats (45 days old) were assigned into 2 groups. Control and cisplatin (CP: 1 mg/kg-d, 5 days/week, for 3 weeks, ip.). Male rats at 66 (end of treatment, acute effects evaluation) and 140 days old (after recovery period, persistent effects evaluation) were mated with females. Fetal and post-natal developments of the offspring sired by treated-male mated in both ages were evaluated, including fertility of adult male offspring. No adverse effects in fetal development or puberty onset were seen in CP offspring. However, testicular descent was delayed and postnatal growth was impaired in these animals (acute effect). Moreover, seminal vesicle weight and epididymal sperm count from adult progeny were affected (acute effects) by paternal CP-exposure. The only persistent effect found was alterations in the spermatogenesis. We conclude that paternal CP-administration during pen-puberty affects reproductive endpoints of the progeny. (C) 2011 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 07/59604-1 - Avaliacao imediata e tardia da funcao reprodutiva, desenvolvimento da progenie e fertilidade da prole masculina adulta de ratos tratados com cisplatina durante a puberdade.
• Beneficiário: Ana Paula Alves Favareto
• Modalidade de apoio: Bolsas no Brasil - Doutorado