Molecular hybridization: a useful tool in the design of new drug prototypes

Autor(es)

Viegas-Júnior, Claudio ; Danuello, Amanda ; Bolzani, Vanderlan da Silva ^[3] ; Barreiro, Eliezer J. ; Fraga, Carlos Alberto Manssour

• Tipo de documento: Artigo Científico
• Fonte: Current Medicinal Chemistry; v. 14, n. 17, p. 1829-1852, July 2007.
• Área do conhecimento: Ciências Exatas e da Terra - Química
• Assunto(s): Fármacos Controle físico-químico de qualidade dos fármacos

Resumo

Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hybrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can result in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this paper, we described several examples of different strategies for drug design, discovery and pharmacomodulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infectious, anticancer, cardio- and neuroactive properties. (AU)