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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Molecular hybridization: a useful tool in the design of new drug prototypes

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Author(s):
Viegas-Júnior, Claudio ; Danuello, Amanda ; Bolzani, Vanderlan da Silva [3] ; Barreiro, Eliezer J. ; Fraga, Carlos Alberto Manssour
Total Authors: 5
Document type: Journal article
Source: Current Medicinal Chemistry; v. 14, n. 17, p. 1829-1852, July 2007.
Field of knowledge: Physical Sciences and Mathematics - Chemistry
Abstract

Molecular hybridization is a new concept in drug design and development based on the combination of pharmacophoric moieties of different bioactive substances to produce a new hybrid compound with improved affinity and efficacy, when compared to the parent drugs. Additionally, this strategy can result in compounds presenting modified selectivity profile, different and/or dual modes of action and reduced undesired side effects. So, in this paper, we described several examples of different strategies for drug design, discovery and pharmacomodulation focused on new innovative hybrid compounds presenting analgesic, anti-inflammatory, platelet anti-aggregating, anti-infectious, anticancer, cardio- and neuroactive properties. (AU)