Abstract
In Brazil, cardiovascular diseases contribute to the increased rate of mortality in allregions, representing 30% of all deaths in the country in individuals between 30 and 69 years. Contribute to the risk factors of cardiovascular disease, dyslipidemia. Dyslipidemia is characterized by changes in serum lipids and may be classified into isolated hypercholesterolemia (high LDL), hypertriglyceridemia (high levels of triglycerides), mixed hyperlipidemia (high LDL and triglycerides), low HDL. These changes contribute to the development of atherosclerosis, characterized by accumulation of lipids in arteries and vessels leading to the formation of atheroma. The latter block or decrease the size of the vessels causing isquêmicos. A therapy for the treatment of dyslipidemia events is accomplished by drugs which reduce serum LDL, such as the statins. This class of drug has low efficacy in raising HDL, a factor that is directly associated with increased risk of developing ischemic heart disease. Many of the patients who use this therapy are still subject to cardiovascular events due to the low plasma HDL. Therapeutic alternatives are used alone or combined with statins for greater effectiveness in the treatment of dyslipidemia, such as fibrates, drugs that promote increased HDL and reduced triglycerides to activate PPAR - ± receptor. However, this class of compounds has limitations in response to treatment side effects when used in combination with statins or not. Resveratrol is a natural compound classified as a polyphenol, and several cardioprotective effects of this compound are described, for example the increase in plasma HDL, LDL and triglyceride reduction. Such properties are related to the antagonism of PPAR- ±. Resveratrol is considered a model for obtaining new prototypes in the development of new drugs dyslipidemia. Molecular hybridization is a strategy for drug discovery which is the union of two different subunits of compounds of known biological activity, for obtaining a new chemical structure with double or synergistic activity. Because current therapy for the treatment of dyslipidemia has limitations, the approach of molecular hybridization is a useful strategy for the discovery of new drugs dyslipidemia. Using molecular hybridization between fibrates and resveratrol we have intended to seek novel, secure and potential compounds for dyslipidemia treatment. (AU)
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