A new scenario of bioprospecting of Hymenoptera venoms through proteomic approach

Autor(es)

Santos, L. D. ^[1] ; Pieroni, M. ^[2] ; Menegasso, A. R. S. ^[3] ; Pinto, J. R. A. S. ^[3] ; Palma, M. S. ^[3]

Afiliação do(s) autor(es)

^[1] UNESP Univ Estadual Paulista, Sao Paulo State Univ, Ctr Study Venoms & Venomous Anim, Botucatu, SP - Brazil

^[2] Univ Sorocaba UNISO, Sorocaba, SP - Brazil

^[3] UNESP Univ Estadual Paulista, Sao Paulo State Univ, Ctr Study Social Insects, Dept Biol, Inst Biosci, Rio Claro, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 17, n. 4, p. 364-377, 2011.
• Citações Web of Science: 22

Resumo

Venoms represent a huge and essentially unexplored reservoir of bioactive components that may cure diseases that do not respond to currently available therapies. This review select advances reported in the literature from 2000 to the present about the new scenario of Hymenoptera venom composition. On account of new technologies in the proteomic approach, which presents high resolution and sensitivity, the combination of developments in new instruments, fragmentation methods, strategic analysis, and mass spectrometry have become indispensable tools for interrogation of protein expression, molecule interaction, and post- translational modifications. Thus, the biochemical characterization of Hymenoptera venom has become a major subject of research in the area of allergy and immunology, in which proteomics has been an excellent alternative to assist the development of more specific extracts for diagnosis and treatment of hypersensitive patients to Hymenoptera venoms. (AU)

• Processo FAPESP: 06/57122-7 - Procura de compostos líderes para o desenvolvimento racional de novos fármacos e pesticidas a partir bioprospecção da fauna de artrópodes brasileiros
• Beneficiário: Mario Sergio Palma
• Modalidade de apoio: Auxílio à Pesquisa - Programa BIOTA - Temático