A new scenario of bioprospecting of Hymenoptera venoms through proteomic approach

Author(s)

Santos, L. D. ^[1] ; Pieroni, M. ^[2] ; Menegasso, A. R. S. ^[3] ; Pinto, J. R. A. S. ^[3] ; Palma, M. S. ^[3]

Affiliation

^[1] UNESP Univ Estadual Paulista, Sao Paulo State Univ, Ctr Study Venoms & Venomous Anim, Botucatu, SP - Brazil

^[2] Univ Sorocaba UNISO, Sorocaba, SP - Brazil

^[3] UNESP Univ Estadual Paulista, Sao Paulo State Univ, Ctr Study Social Insects, Dept Biol, Inst Biosci, Rio Claro, SP - Brazil

• Document type: Journal article
• Source: Journal of Venomous Animals and Toxins including Tropical Diseases; v. 17, n. 4, p. 364-377, 2011.
• Web of Science Citations: 22

Abstract

Venoms represent a huge and essentially unexplored reservoir of bioactive components that may cure diseases that do not respond to currently available therapies. This review select advances reported in the literature from 2000 to the present about the new scenario of Hymenoptera venom composition. On account of new technologies in the proteomic approach, which presents high resolution and sensitivity, the combination of developments in new instruments, fragmentation methods, strategic analysis, and mass spectrometry have become indispensable tools for interrogation of protein expression, molecule interaction, and post- translational modifications. Thus, the biochemical characterization of Hymenoptera venom has become a major subject of research in the area of allergy and immunology, in which proteomics has been an excellent alternative to assist the development of more specific extracts for diagnosis and treatment of hypersensitive patients to Hymenoptera venoms. (AU)

• FAPESP's process: 06/57122-7 - Searching for lead compounds for rational development of new drugs and pesticides through bioprospecting in Brazilian arthropods
• Grantee: Mario Sergio Palma
• Support Opportunities: BIOTA-FAPESP Program - Thematic Grants