In sickness and in health: the widespread application of creatine supplementation

Autor(es)

Gualano, Bruno ^[1] ; Roschel, Hamilton ^[1] ; Lancha, Jr., Antonio Herbert ^[1] ; Brightbill, Charles E. ^[2] ; Rawson, Eric S. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo - Brazil

^[2] Bloomsburg Univ Penn, Dept Exercise Sci, Bloomsburg, PA 17815 - USA

• Tipo de documento: Artigo de Revisão
• Fonte: Amino Acids; v. 43, n. 2, p. 519-529, AUG 2012.
• Citações Web of Science: 69

Resumo

There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application of Cr supplementation is indeed exciting. Evidences of benefits from this supplement have been reported in a broad range of diseases, including myopathies, neurodegenerative disorders, cancer, rheumatic diseases, and type 2 diabetes. In addition, after hundreds of published studies and millions of exposures creatine supplementation maintains an excellent safety profile. Thus, we contend that the widespread application of this supplement may benefit athletes, elderly people and various patient populations. In this narrative review, we aimed to summarize both the ergogenic and therapeutic effects of Cr supplementation. Furthermore, we reviewed the impact of Cr supplementation on kidney function. (AU)

• Processo FAPESP: 10/18708-1 - Eficácia e segurança da suplementação de cretaina em pacientes com dermatomiosite de início juvenil e lúpus eritematoso sistêmico de início juvenil
• Beneficiário: Bruno Gualano
• Modalidade de apoio: Auxílio à Pesquisa - Regular