| Full text | |
| Author(s): |
Gualano, Bruno
[1]
;
Roschel, Hamilton
[1]
;
Lancha, Jr., Antonio Herbert
[1]
;
Brightbill, Charles E.
[2]
;
Rawson, Eric S.
[2]
Total Authors: 5
|
| Affiliation: | [1] Univ Sao Paulo, Sch Phys Educ & Sport, BR-05508030 Sao Paulo - Brazil
[2] Bloomsburg Univ Penn, Dept Exercise Sci, Bloomsburg, PA 17815 - USA
Total Affiliations: 2
|
| Document type: | Review article |
| Source: | Amino Acids; v. 43, n. 2, p. 519-529, AUG 2012. |
| Web of Science Citations: | 69 |
| Abstract | |
There is an extensive and still growing body of the literature supporting the efficacy of creatine (Cr) supplementation. In sports, creatine has been recognized as the most effective nutritional supplement in enhancing exercise tolerance, muscle strength and lean body mass. From a clinical perspective, the application of Cr supplementation is indeed exciting. Evidences of benefits from this supplement have been reported in a broad range of diseases, including myopathies, neurodegenerative disorders, cancer, rheumatic diseases, and type 2 diabetes. In addition, after hundreds of published studies and millions of exposures creatine supplementation maintains an excellent safety profile. Thus, we contend that the widespread application of this supplement may benefit athletes, elderly people and various patient populations. In this narrative review, we aimed to summarize both the ergogenic and therapeutic effects of Cr supplementation. Furthermore, we reviewed the impact of Cr supplementation on kidney function. (AU) | |
| FAPESP's process: | 10/18708-1 - Efficacy and safety of creatine supplementation in patients with juvenile onset dermatomyositis and juvenile onset systemic lupus erythematosus |
| Grantee: | Bruno Gualano |
| Support Opportunities: | Regular Research Grants |