| Texto completo | |
| Autor(es): |
Metidieri, Hugo Tadeu
[1]
;
Mancio, Rafael Dias
[1]
;
Mayoral, Eber Emanuel
[1]
;
Rojas, Fernanda Alvarez
[1]
;
Peroni, Luis Antonio
[1]
;
Ferri, Alan Telles
[1]
;
Lourenco, Edmir Americo
[1]
;
Caldeira, Eduardo Jose
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] FMJ, Fac Med Jundiai, Dept Morphol & Basic Pathol, Tissue Morphol Lab, Sao Paulo - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | MICROSCOPY RESEARCH AND TECHNIQUE; v. 75, n. 7, p. 928-934, JUL 2012. |
| Citações Web of Science: | 2 |
| Resumo | |
Background: Diabetes mellitus results in many complications, also compromising the salivary glands. The current treatment for this condition should be a substituting method to exogenous insulin. In this aspect, the immunotherapy has been tested, but, it can be inefficient as an agent for the control of damage caused by diabetes. Thus, the aim of this study was to evaluate the anti-CD3 monoclonal antibody as alternative immunotherapy in the recovery of salivary glands of spontaneously diabetic NOD (nonobese diabetic) mice. Methods: NOD mice were divided into two groups of 10 animals: group I (untreated diabetic mice) and group II (anti-CD3-treated diabetic mice). After treatment, the samples of salivary glands were collected for histological examination under both transmitted and polarized light microscopy. Results: Alterations in tissue architecture; increase in extracellular matrix and presence of inflammatory process were observed in untreated animals. Recovery of the salivary acinar cells occurred in treated animals. The parotid glands demonstrated a smaller amount of collagen fibers and were not observed severe inflammatory processes. Conclusion: These results indicate that immunotherapy contributed to reestablishment of tissue damaged by the hyperglycemic condition, demonstrating that the immunomodulation plays an important role in the recovery of salivary glands. Microsc. Res. Tech., 2012. (C) 2012 Wiley Periodicals, Inc. (AU) | |
| Processo FAPESP: | 10/05455-8 - Efeitos do tratamento com anti-CD3 (OKT3) sobre as glândulas salivares de camundongos diabéticos espontâneos |
| Beneficiário: | Hugo Tadeu Metidieri |
| Modalidade de apoio: | Bolsas no Brasil - Iniciação Científica |
| Processo FAPESP: | 10/51619-2 - Influencia do tratamento com okt-3 e mko-431 sobre a expressao dos receptores de insulina em glandulas salivares de camundongos espontaneamente diabeticos. |
| Beneficiário: | Eduardo José Caldeira |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |