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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Effects of anti-CD3 monoclonal antibody in salivary glands of spontaneously diabetic mice

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Author(s):
Metidieri, Hugo Tadeu [1] ; Mancio, Rafael Dias [1] ; Mayoral, Eber Emanuel [1] ; Rojas, Fernanda Alvarez [1] ; Peroni, Luis Antonio [1] ; Ferri, Alan Telles [1] ; Lourenco, Edmir Americo [1] ; Caldeira, Eduardo Jose [1]
Total Authors: 8
Affiliation:
[1] FMJ, Fac Med Jundiai, Dept Morphol & Basic Pathol, Tissue Morphol Lab, Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: MICROSCOPY RESEARCH AND TECHNIQUE; v. 75, n. 7, p. 928-934, JUL 2012.
Web of Science Citations: 2
Abstract

Background: Diabetes mellitus results in many complications, also compromising the salivary glands. The current treatment for this condition should be a substituting method to exogenous insulin. In this aspect, the immunotherapy has been tested, but, it can be inefficient as an agent for the control of damage caused by diabetes. Thus, the aim of this study was to evaluate the anti-CD3 monoclonal antibody as alternative immunotherapy in the recovery of salivary glands of spontaneously diabetic NOD (nonobese diabetic) mice. Methods: NOD mice were divided into two groups of 10 animals: group I (untreated diabetic mice) and group II (anti-CD3-treated diabetic mice). After treatment, the samples of salivary glands were collected for histological examination under both transmitted and polarized light microscopy. Results: Alterations in tissue architecture; increase in extracellular matrix and presence of inflammatory process were observed in untreated animals. Recovery of the salivary acinar cells occurred in treated animals. The parotid glands demonstrated a smaller amount of collagen fibers and were not observed severe inflammatory processes. Conclusion: These results indicate that immunotherapy contributed to reestablishment of tissue damaged by the hyperglycemic condition, demonstrating that the immunomodulation plays an important role in the recovery of salivary glands. Microsc. Res. Tech., 2012. (C) 2012 Wiley Periodicals, Inc. (AU)

FAPESP's process: 10/05455-8 - Effects of the anti-CD3 (OKT3) treatment in the salivary glands of spontaneous diabetic mice
Grantee:Hugo Tadeu Metidieri
Support Opportunities: Scholarships in Brazil - Scientific Initiation