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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Influence of Maternal Hyperglycemia on IL-10 and TNF-alpha Production: The Relationship with Perinatal Outcomes

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Autor(es):
Moreli, Jusciele Brogin [1] ; Morceli, Glilciane [1] ; De Luca, Ana Karina C. [2] ; Magalhaes, Claudia G. [2] ; Costa, Roberto A. A. [2] ; Damasceno, Debora Cristina [2, 1] ; Cunha Rudge, Marilza Vieira [2, 1] ; Paranhos Calderon, Iracema Mattos [2, 1]
Número total de Autores: 8
Afiliação do(s) autor(es):
[1] UNESP Sao Paulo State Univ, Postgrad Program Gynecol Obstet & Mastol, Botucatu Med Sch, Botucatu, SP - Brazil
[2] UNESP Sao Paulo State Univ, Dept Obstet & Gynecol, Botucatu Med Sch, BR-18618000 Sao Paulo - Brazil
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Fonte: JOURNAL OF CLINICAL IMMUNOLOGY; v. 32, n. 3, p. 604-610, JUN 2012.
Citações Web of Science: 17
Resumo

Aims This study was conducted to evaluate maternal and placental concentrations of interleukin 10 (IL-10) and tumor necrosis factor-alpha (TNF-alpha) in pregnant women with glycemic mean (GM) < or >= 100 mg/dL, as well as correlate IL-10 and TNF-alpha placental concentrations with perinatal outcomes. Methods One hundred eighty-six pregnant women were distributed in groups determined by a GM < 100 mg/dL or a GM >= 100 mg/dL. The GM, HbA1c levels, maternal and placental concentrations of IL-10 and TNF-alpha, and the correlation of placental cytokines with perinatal outcomes were evaluated. Results In maternal blood, the lowest concentrations of IL-10 (p=00.0019) and TNF-alpha (p=0.0185) were observed in the GM >= 100-mg/dL group. The placentas from GM >= 100 mg/dL group exhibited higher TNF-alpha concentrations (p=0.0385). Placental IL-10 directly correlated with hemoglobin (r=0.63; p=0.02) and insulin (r=0.78; p=0.01) levels in the umbilical cord and with 1-min (r=0.53; p=0.0095) and 5-min (r=0.69; p=0.0003) Apgar scores. Placental TNF-alpha displayed a tendency to inversely correlate with fetal weight (r=-0.41; p=0.05). Conclusion Compared to GM<100 mg/dL, GM >= 100 mg/dL was associated with a reduction in maternal IL-10 and TNF-alpha concentrations and increased placental TNF-alpha production. Placental IL-10 production was similar in both groups studied and directly correlated with hemoglobin and umbilical cord insulin levels, as well as with the 1- and 5-min Apgar scores. (AU)

Processo FAPESP: 09/03253-1 - IL-10 e TNF alfa no sangue materno e nas placentas de gestações complicadas por diabete ou hiperglicemia leve - correlação com controle glicêmico e resultados perinatais
Beneficiário:Jusciele Brogin Moreli
Modalidade de apoio: Bolsas no Brasil - Mestrado