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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Segregated anatomical input to sub-regions of the rodent superior colliculus associated with approach and defense

Texto completo
Comoli, Eliane [1] ; Favaro, Plinio Das Neves [1] ; Vautrelle, Nicolas [2] ; Leriche, Mariana [2] ; Overton, Paul G. [2] ; Redgrave, Peter [2]
Número total de Autores: 6
Afiliação do(s) autor(es):
[1] Univ Sao Paulo, Sch Med Ribeirao Preto, Lab Funct Neuroanat, Dept Physiol, BR-14049900 Ribeirao Preto, SP - Brazil
[2] Univ Sheffield, Dept Psychol, Sheffield S10 2TN, S Yorkshire - England
Número total de Afiliações: 2
Tipo de documento: Artigo Científico
Citações Web of Science: 58

The superior colliculus (SC) is responsible for sensorimotor transformations required to direct gaze toward or a way from unexpected, biologically salient events. Significant changes in the external world are signaled to SC through primary multisensory afferents, spatially organized according to a retinotopic topography. For animals, where anunexpected event could indicate the presence of either predator or prey, early decisions to approach or avoid are particularly important. Rodents' ecology dictates predators are most often detected initially as movements in upper visual field (mapped in medial SC), while appetitive stimuli are normally found in lower visual field (mapped in lateral SC). Our purpose was to exploit this functional segregation to reveal neural sites that can bias or modulate initial approach or avoidance responses. Small injections of Fluoro-Gold were made into medial or lateral sub-regions of intermediate and deep layers of SC (SCm/SCl). A remarkable segregation of input to these two functionally defined areas was found. (i) There were structures that projected only to SCm (e.g., specific cortical areas, lateral geniculate and suprageniculate thalamic nuclei, ventromedial and premammillary hypothalamic nuclei, and several brain-stem areas) or SCl (e.g., primary somatosensory cortex representing upper body parts and vibrissae and parvicellular reticular nucleus in the brainstem). (ii) Other structures projected to both SCm and SCl but from topographically segregated populations of neurons (e.g., zona incerta and substantia nigra pars reticulata). (iii) There were a few brainstem areas in which retrogradely labeled neurons were spatially overlapping (e.g., pedunculopontine nucleus and locus coeruleus). These results indicate significantly more structures across the rat neuraxis are in a position to modulate defense responses evoked from SCm, and that neural mechanisms modulating SC-mediated defense or appetitive behavior are almost entirely segregated. (AU)

Processo FAPESP: 06/03655-4 - Estudo anátomo-funcional das alças sub-corticais dos gânglios da base envolvendo das camadas intermediárias do colículo superior no comportamento predatório em ratos
Beneficiário:Eliane Comoli
Linha de fomento: Auxílio à Pesquisa - Apoio a Jovens Pesquisadores