Repeated administration of caffeine induces either sensitization or tolerance of locomotor stimulation depending on the environmental context

Autor(es)

Zancheta, Roberta ^{[1, 2]} ; Possi, Ana P. M. ^{[1, 2]} ; Planeta, Cleopatra S. ^{[1, 2]} ; Marin, Marcelo T. ^{[1, 3]}

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista UNESP, Sch Pharmaceut Sci, Pharmacol Lab, BR-14801902 Araraquara, SP - Brazil

^[2] UFSCar UNESP, Interinst Grad Program Physiol Sci, BR-13565905 Sao Carlos, SP - Brazil

^[3] Fed Univ Uberlandia UFU, Inst Biomed Sci, BR-38400902 Uberlandia, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: PHARMACOLOGICAL REPORTS; v. 64, n. 1, p. 70-77, JAN-FEB 2012.
• Citações Web of Science: 12

Resumo

Caffeine is the psychostimulant substance consumed in greatest quantities in the world. The repeated administration of psychostimulants can either decrease or increase the drug effect, inducing tolerance or sensitization, respectively, depending on administration procedure. Not only the dose and regimen, but also the environment where drug is administered, seem to modulate the changes in locomotor activity following repeated psychostimulant administration. The purpose of the present study was to examine the influence of the environmental context on caffeine-induced psychomotor stimulation following repeated administration of this drug. Our results showed that repeated caffeine induced psychomotor sensitization when drug injections were paired with the environment in which the animals were subsequently tested, whereas tolerance occurred when the animals received repeated caffeine in an environment different from that where the tests were performed. In conclusion, the present results demonstrated that the environmental context where caffeine is administered is a key factor modulating the adaptations of the organism to drug effects. (AU)

• Processo FAPESP: 07/57542-9 - Tolerância e sensibilização comportamental a cafeína: aspectos comportamentais e neuroquímicos
• Beneficiário: Roberta Zancheta
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 07/57541-2 - Efeitos da cafeina na transmissao serotonergica e dopaminergica em ratos adultos e adolescentes.
• Beneficiário: Ana Paula Marques Possi
• Modalidade de apoio: Bolsas no Brasil - Mestrado
• Processo FAPESP: 08/01744-5 - Estresse e auto-administração de nicotina: envolvimento da via de transdução CREB, PKA e ERK no sistema dopaminérgico mesocorticolímbico
• Beneficiário: Cleopatra da Silva Planeta
• Modalidade de apoio: Auxílio à Pesquisa - Regular