Post-surgical follow-up of primary hyperparathyroidism associated with multiple endocrine neoplasia type 1

Autor(es)

Coutinho, Flavia L. ^[1] ; Lourenco, Jr., Delmar M. ^[1] ; Toledo, Rodrigo A. ^[1] ; Montenegro, Fabio L. M. ^[2] ; Toledo, Sergio P. A. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Hosp Clin, Div Endocrinol, Endocrine Genet Unit LIM 25, BR-05508 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Hosp Clin, Dept Head & Neck Surg, BR-05508 Sao Paulo - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Clinics; v. 67, n. 1, p. 169-172, 2012.
• Citações Web of Science: 7

Resumo

The bone mineral density increments in patients with sporadic primary hyperparathyroidism after parathyroidectomy have been studied by several investigators, but few have investigated this topic in primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Further, as far as we know, only two studies have consistently evaluated bone mineral density values after parathyroidectomy in cases of primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Here we revised the impact of parathyroidectomy (particularly total parathyroidectomy followed by autologous parathyroid implant into the forearm) on bone mineral density values in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1. Significant increases in bone mineral density in the lumbar spine and femoral neck values were found, although no short-term (15 months) improvement in bone mineral density at the proximal third of the distal radius was observed. Additionally, short-term and medium-term calcium and parathyroid hormone values after parathyroidectomy in patients with primary hyperparathyroidism associated with multiple endocrine neoplasia type 1 are discussed. In most cases, this surgical approach was able to restore normal calcium/parathyroid hormone levels and ultimately lead to discontinuation of calcium and calcitriol supplementation. (AU)

• Processo FAPESP: 09/15386-6 - Análise dos genes CDKN1A, CDKN1B, CDKN2B e CDKN2C, nas neoplasias endócrinas múltiplas tipo 1 e 2.
• Beneficiário: Rodrigo de Almeida Toledo
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado