ANTI-MYCOBACTERIUM TUBERCULOSIS ACTIVITY OF FUNGUS PHOMOPSIS STIPATA

Autor(es)

de Prince, Karina Andrade ^{[1, 2]} ; Sordi, Renata ^[3] ; Pavan, Fernando Rogerio ^[1] ; Barreto Santos, Adolfo Carlos ^[1] ; Araujo, Angela R. ^[3] ; Leite, Sergio R. A. ^[3] ; Leite, Clarice Q. F. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Fac Ciencias Farmaceut, Araraquara, SP - Brazil

^[2] Fac Integradas Pitagoras, Montes Claros, MG - Brazil

^[3] Univ Estadual Paulista, Inst Quim, Araraquara, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Brazilian Journal of Microbiology; v. 43, n. 1, p. 224-229, JAN-MAR 2012.
• Citações Web of Science: 3

Resumo

Our purpose was to determine the anti-Mycobacterium tuberculosis activity of the metabolites produced by the endophitic fungus Phomopsis stipata (Lib.) B. Sutton, (Diaporthaceae), cultivated in different media. The antimycobacterial activity was assessed through the Resazurin Microtiter Assay (REMA) and the cytotoxicity test performed on macrophage cell line. The extracts derived from fungi grown on Corn Medium and Potato Dextrose Broth presented the smallest values of Minimum Inhibitory Concentration (MIC) and low cytotoxicity, which implies a high selectivity index. This is the first report on the chemical composition and antitubercular activity of metabolites of P. stipata, as well as the influence of culture medium on these properties. (AU)

• Processo FAPESP: 11/11593-7 - Pesquisa de novos fármacos contra tuberculose: implementação laboratorial para realizar ensaios pré-clínicos
• Beneficiário: Fernando Rogério Pavan
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 08/10390-2 - Determinação do perfil pré-clínico da atividade antituberculose in vitro e in vivo dos complexos de rutênio(II)fosfinas / diiminas
• Beneficiário: Fernando Rogério Pavan
• Modalidade de apoio: Bolsas no Brasil - Doutorado