Progestin-only contraception prevents bone loss in postpartum breastfeeding women

Autor(es)

Costa, Maria Laura ^[1] ; Cecatti, Jose Guilherme ^[1] ; Krupa, Fabiana G. ^[1] ; Rehder, Patricia Moretti ^[1] ; Sousa, Maria Helena ^[1] ; Costa-Paiva, Lucia ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Sch Med Sci, Dept Obstet & Gynecol, BR-13083881 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Contraception; v. 85, n. 4, p. 374-380, APR 2012.
• Citações Web of Science: 8

Resumo

Background: There are an increase in bone loss during the first 6 months postpartum and a complete recovery postweaning. A few studies of steroid contraceptive use during this period provide some evidence towards protection of bone loss with progestin-only contraceptive methods. Objective: The study was conducted to evaluate forearm bone mineral density (BMD) of breastfeeding postpartum women using nonhormonal and progestin-only contraceptive methods. Study Design: A prospective cohort study of postpartum women had an analysis performed at 6 months postpartum correlating BMD with contraceptive use. Forearm BMD was measured 7-10 days, 3 months and 6 months postpartum. Eighty-two women were analyzed, comparing nonhormonal (54) and progestin-only (28) contraceptive methods. Information about breastfeeding duration, amenorrhea and body mass index was collected. Results: Baseline characteristics of the study population showed no statistical differences between the groups. The median duration of breastfeeding for both groups was 183 days. A significant BMD decrease was observed for the nonhormonal group (p<.001); however, no statistical difference was detected for the progestin-only group. Body mass index, BMD at 7-10 days postpartum and total duration of breastfeeding were positively correlated with BMD at 6 months. Conclusions: Our findings suggest a preventive effect towards postpartum bone loss with progestin-only contraception in breastfeeding women. (C) 2012 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 06/04555-3 - Associação da lactação com a densidade mineral óssea (DMO) no puerpério
• Beneficiário: José Guilherme Cecatti
• Modalidade de apoio: Auxílio à Pesquisa - Regular