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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Progestin-only contraception prevents bone loss in postpartum breastfeeding women

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Author(s):
Costa, Maria Laura [1] ; Cecatti, Jose Guilherme [1] ; Krupa, Fabiana G. [1] ; Rehder, Patricia Moretti [1] ; Sousa, Maria Helena [1] ; Costa-Paiva, Lucia [1]
Total Authors: 6
Affiliation:
[1] Univ Estadual Campinas, Sch Med Sci, Dept Obstet & Gynecol, BR-13083881 Sao Paulo - Brazil
Total Affiliations: 1
Document type: Journal article
Source: Contraception; v. 85, n. 4, p. 374-380, APR 2012.
Web of Science Citations: 8
Abstract

Background: There are an increase in bone loss during the first 6 months postpartum and a complete recovery postweaning. A few studies of steroid contraceptive use during this period provide some evidence towards protection of bone loss with progestin-only contraceptive methods. Objective: The study was conducted to evaluate forearm bone mineral density (BMD) of breastfeeding postpartum women using nonhormonal and progestin-only contraceptive methods. Study Design: A prospective cohort study of postpartum women had an analysis performed at 6 months postpartum correlating BMD with contraceptive use. Forearm BMD was measured 7-10 days, 3 months and 6 months postpartum. Eighty-two women were analyzed, comparing nonhormonal (54) and progestin-only (28) contraceptive methods. Information about breastfeeding duration, amenorrhea and body mass index was collected. Results: Baseline characteristics of the study population showed no statistical differences between the groups. The median duration of breastfeeding for both groups was 183 days. A significant BMD decrease was observed for the nonhormonal group (p<.001); however, no statistical difference was detected for the progestin-only group. Body mass index, BMD at 7-10 days postpartum and total duration of breastfeeding were positively correlated with BMD at 6 months. Conclusions: Our findings suggest a preventive effect towards postpartum bone loss with progestin-only contraception in breastfeeding women. (C) 2012 Elsevier Inc. All rights reserved. (AU)