| Texto completo | |
| Autor(es): |
Martinewski, Alexandre
[1]
;
Correia, Caio S. C.
[1]
;
de Souza, Nivea L.
[1]
;
Merusse, Jose L. B.
[1]
Número total de Autores: 4
|
| Afiliação do(s) autor(es): | [1] Univ Sao Paulo, Dept Pathol, Sch Vet Med, Sao Paulo - Brazil
Número total de Afiliações: 1
|
| Tipo de documento: | Artigo Científico |
| Fonte: | Journal of the American Association for Laboratory Animal Science; v. 51, n. 2, p. 177-180, MAR 2012. |
| Citações Web of Science: | 2 |
| Resumo | |
We performed the initial assessment of an alternative pressurized intraventilated (PIV) caging system for laboratory mice that uses direct-current microfans to achieve cage pressurization and ventilation. Twenty-nine pairs of female SPF BALB/c mice were used, with 19 experimental pairs kept in Ply cages and 10 control pairs kept in regular filter-top (FT) cages. Both groups were housed in a standard housing room with a conventional atmospheric control system. For both systems, intracage temperatures were in equilibrium with ambient room temperature. PIV cages showed a significant difference in pressure between days 1 and 8. Air speed (and consequently airflow rate) and the number of air changes hourly in the PIV cages showed decreasing trends. In both systems, ammonia concentrations increased with time, with significant differences between groups starting on day 1. Overall, the data revealed that intracage pressurization and ventilation by using microfans is a simple, reliable system, with low cost, maintenance requirements, and incidence of failures. Further experiments are needed to determine the potential influence of this system on the reproductive performance and pulmonary integrity in mice. (AU) | |
| Processo FAPESP: | 98/15314-9 - Sistema de ventilação microambiental para biotérios com o uso de micro ventiladores de corrente contínua |
| Beneficiário: | José Luiz Bernardino Merusse |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |