Paracoccidioidomycosis: Cells expressing IL17 and Foxp3 in cutaneous and mucosal lesions

Autor(es)

Pagliari, Carla ^[1] ; Fernandes, Elaine Raniero ^[1] ; Stegun, Felipe Weisshaupt ^[1] ; da Silva, Wellington Luiz F. ^[1] ; Seixas Duarte, Maria Irma ^[1] ; Sotto, Mirian N. ^{[1, 2]}

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Lab Disciplina Patol Molestias Transmissiveis, Dept Patol, BR-01246903 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Fac Med, Dept Dermatol, Lab Dermatopatol, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Microbial Pathogenesis; v. 50, n. 5, p. 263-267, MAY 2011.
• Citações Web of Science: 19

Resumo

We demonstrated and quantified by immunohistochemistry the population of cells expressing IL17 and Foxp3 in cutaneous and mucosal paracoccidioidomycosis lesions, associating these populations of cells with different presentations of granulomatous response. For this purpose, 61 skin biopsies and 55 oral mucosal biopsies were evaluated. Cells expressing IL17 were distributed in the inflammatory infiltrate in both groups of lesions and were found in the vessels' wall too. Foxp3+ expression was limited to the nuclei of lymphocytes in the inflammatory infiltrate. The distribution of IL17 was similar among the groups; however, Foxp3+ cells were increased in mucosal lesions that displayed compact granulomas. The results suggest that IL17 seems to play a role in paracoccidioidomycosis cutaneous and mucosal lesions, probably as secondary cells in the clearance of the fungal antigens. The presence of Foxp3+ cells both in skin and mucosa corroborates some previous researches that suggest the role of this group of cells in the modulation of local immune response. (C) 2011 Elsevier Ltd. All rights reserved. (AU)

• Processo FAPESP: 08/09355-8 - Resposta imune in situ na Paracoccidioidomicose: células de perfil Th17 e células T regulatórias FOXP3 e interação do Paracoccidioides brasiliensis com elementos celulares das lesões cutâneas e mucosas
• Beneficiário: Carla Pagliari
• Modalidade de apoio: Auxílio à Pesquisa - Regular