Use of Bovine Hydroxyapatite With or Without Biomembrane in Sinus Lift in Rabbits: Histopathologic Analysis and Immune Expression of Core Binding Factor 1 and Vascular Endothelium Growth Factor

Autor(es)

De Souza Nunes, Leandro Soeiro ^[1] ; De Oliveira, Renato Victor ^[1] ; Holgado, Leandro Andrade ^[1] ; Nary Filho, Hugo ^[2] ; Ribeiro, Daniel Araki ^[3] ; Matsumoto, Mariza Akemi ^[1]

Afiliação do(s) autor(es)

^[1] Sagrado Coracao Univ, Discipline Oral & Maxillofacial Surg, Sch Dent, Dept Hlth Sci, Bauru, SP - Brazil

^[2] PI Branemark Inst, Bauru, SP - Brazil

^[3] Univ Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY; v. 69, n. 4, p. 1064-1069, APR 2011.
• Citações Web of Science: 9

Resumo

Purpose: Considering the clinical discussion on the necessity of using a barrier membrane in the osteotomy area of sinus lift procedures to prevent fibrous tissue formation in this area and as a physical limit, the aim of this study was to analyze and compare the use of bovine hydroxyapatite (HA) with and without a biologic membrane by histopathologic analysis and immune expression of core binding factor 1 and vascular endothelium growth factor in the sinus lift in rabbits. Materials and Methods: Sixteen male rabbits underwent bilateral sinus lift procedures and were divided into 2 groups according to the sinus filling material: group 1 received bovine HA (Bio-Oss; Geistlich Pharma AG, Wohlhusen, Switzerland) and group 2 received bovine HA and a nonporous polytetrafluorethylene membrane. All groups were sacrificed after 7, 14, 30, and 60 days for microscopic, histomorphometric, and immunohistochemical analyses. Results: Microscopic analysis showed a similar bone repair pattern between the tested groups. New bone formation, soft tissue, and the remaining material were analyzed by histomorphometric analysis. No statistically significant differences (P > .05) were detected between groups for all periods analyzed. In addition, no remarkable differences were noticed in core binding factor 1 or vascular endothelium growth factor immune expression. Conclusion: Taken together, these results show that using a biologic membrane does not improve bone repair induced by bovine HA, as shown by histopathologic and immunohistochemical analyses. (C) 2011 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 69:1064-1069, 2011 (AU)

• Processo FAPESP: 07/04767-3 - Biocompatibilidade de polietileno poroso de alta densidade, hidroxiapatita bovina inorgânica e b-tricalcio fosfato em coelhos: parâmetros morfológicos macro e microscópicos e imunoistoquímicos
• Beneficiário: Mariza Akemi Matsumoto
• Modalidade de apoio: Auxílio à Pesquisa - Regular