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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Use of Bovine Hydroxyapatite With or Without Biomembrane in Sinus Lift in Rabbits: Histopathologic Analysis and Immune Expression of Core Binding Factor 1 and Vascular Endothelium Growth Factor

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Author(s):
De Souza Nunes, Leandro Soeiro [1] ; De Oliveira, Renato Victor [1] ; Holgado, Leandro Andrade [1] ; Nary Filho, Hugo [2] ; Ribeiro, Daniel Araki [3] ; Matsumoto, Mariza Akemi [1]
Total Authors: 6
Affiliation:
[1] Sagrado Coracao Univ, Discipline Oral & Maxillofacial Surg, Sch Dent, Dept Hlth Sci, Bauru, SP - Brazil
[2] PI Branemark Inst, Bauru, SP - Brazil
[3] Univ Fed Sao Paulo, Dept Biociencias, BR-11060001 Santos, SP - Brazil
Total Affiliations: 3
Document type: Journal article
Source: JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY; v. 69, n. 4, p. 1064-1069, APR 2011.
Web of Science Citations: 9
Abstract

Purpose: Considering the clinical discussion on the necessity of using a barrier membrane in the osteotomy area of sinus lift procedures to prevent fibrous tissue formation in this area and as a physical limit, the aim of this study was to analyze and compare the use of bovine hydroxyapatite (HA) with and without a biologic membrane by histopathologic analysis and immune expression of core binding factor 1 and vascular endothelium growth factor in the sinus lift in rabbits. Materials and Methods: Sixteen male rabbits underwent bilateral sinus lift procedures and were divided into 2 groups according to the sinus filling material: group 1 received bovine HA (Bio-Oss; Geistlich Pharma AG, Wohlhusen, Switzerland) and group 2 received bovine HA and a nonporous polytetrafluorethylene membrane. All groups were sacrificed after 7, 14, 30, and 60 days for microscopic, histomorphometric, and immunohistochemical analyses. Results: Microscopic analysis showed a similar bone repair pattern between the tested groups. New bone formation, soft tissue, and the remaining material were analyzed by histomorphometric analysis. No statistically significant differences (P > .05) were detected between groups for all periods analyzed. In addition, no remarkable differences were noticed in core binding factor 1 or vascular endothelium growth factor immune expression. Conclusion: Taken together, these results show that using a biologic membrane does not improve bone repair induced by bovine HA, as shown by histopathologic and immunohistochemical analyses. (C) 2011 American Association of Oral and Maxillofacial Surgeons J Oral Maxillofac Surg 69:1064-1069, 2011 (AU)

FAPESP's process: 07/04767-3 - High density porous polyethylene, inorganic bovine hydroxyapatite, and B-tricalcium phosphate tissue response in rabbits: morphological macroscopic and microscopic analalysis and immunohistochemistry
Grantee:Mariza Akemi Matsumoto
Support Opportunities: Regular Research Grants