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High density porous polyethylene, inorganic bovine hydroxyapatite, and B-tricalcium phosphate tissue response in rabbits: morphological macroscopic and microscopic analalysis and immunohistochemistry

Grant number: 07/04767-3
Support Opportunities:Regular Research Grants
Duration: December 01, 2007 - November 30, 2009
Field of knowledge:Health Sciences - Dentistry - Oral and Maxillofacial Surgery
Principal Investigator:Mariza Akemi Matsumoto
Grantee:Mariza Akemi Matsumoto
Host Institution: Centro de Ciências Biológicas e Profissões da Saúde. Universidade do Sagrado Coração (USC). Bauru , SP, Brazil


A number of biomaterials used as bone substitutes and to improve bone repair and formation have been used, especially for ridge reconstruction aiming oral rehabilitation with end osseous implants. However, their biological behavior in molecular level needs more investigation. The aim of the present study is to evaluate the biocompatibility of materials commonly used in clinical practice: high density porous polyethylene (HDPP), inorganic bovine hydroxyapatite and B-tricalcium phosphate, comparing with particulate autogenous bone. In this way, New Zealand rabbits will receive HDPP implants in alveolar ridge (masticatory mucosa), or inorganic bovine hydroxyapatite or B-tricalcium phosphate, both implanted in maxillary sinus with or without a non-resorbable membrane. After 7, 15, 45, and 90 days the animals will be sacrificed and the specimens retrieved to be evaluated in their morphological and immunohistochemical aspects under optical microscope. (AU)

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Scientific publications
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
CHAVES, MARCELO DONIZETI; DE SOUZA NUNES, LEANDRO SOEIRO; DE OLIVEIRA, RENATO VICTOR; HOLGADO, LEANDRO ANDRADE; NARY FILHO, HUGO; MATSUMOTO, MARIZA AKEMI; RIBEIRO, DANIEL ARAKI. Bovine hydroxyapatite (Bio-Oss (R)) induces osteocalcin, RANK-L and osteoprotegerin expression in sinus lift of rabbits. JOURNAL OF CRANIO-MAXILLOFACIAL SURGERY, v. 40, n. 8, p. E315-E320, . (07/04767-3)
DE SOUZA NUNES, LEANDRO SOEIRO; DE OLIVEIRA, RENATO VICTOR; HOLGADO, LEANDRO ANDRADE; NARY FILHO, HUGO; RIBEIRO, DANIEL ARAKI; MATSUMOTO, MARIZA AKEMI. Use of Bovine Hydroxyapatite With or Without Biomembrane in Sinus Lift in Rabbits: Histopathologic Analysis and Immune Expression of Core Binding Factor 1 and Vascular Endothelium Growth Factor. JOURNAL OF ORAL AND MAXILLOFACIAL SURGERY, v. 69, n. 4, p. 1064-1069, . (07/04767-3)

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