| Texto completo | |
| Autor(es): |
Lima, Marcelo M. O.
[1]
;
Pareja, Jose C.
[1, 2]
;
Alegre, Sarah M.
[3]
;
Geloneze, Sylka R.
[1]
;
Kahn, Steven E.
[4]
;
Astiarraga, Brenno D.
[1, 3]
;
Chaim, Elinton A.
[2]
;
Geloneze, Bruno
[1]
Número total de Autores: 8
|
| Afiliação do(s) autor(es): | [1] State Univ Campinas UNICAMP, Lab Invest Metab & Diabet Gastroctr, BR-13081970 Campinas, SP - Brazil
[2] State Univ Campinas UNICAMP, Dept Surg, BR-13081970 Campinas, SP - Brazil
[3] State Univ Campinas UNICAMP, Dept Internal Med, BR-13081970 Campinas, SP - Brazil
[4] Vet Affairs Puget Sound Hlth Care Syst, Div Metab Endocrinol & Nutr, Dept Med, Seattle, WA 98108 - USA
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM; v. 95, n. 8, p. 3871-3875, AUG 2010. |
| Citações Web of Science: | 72 |
| Resumo | |
Context: Insulin resistance ameliorates after bariatric surgery, yet there is still a need for data on the acute effect of Roux-en-Y gastric bypass (RYGBP) on insulin sensitivity. Objective: The objective of the study was to describe the acute effect of RYGBP on insulin sensitivity, measured by both the euglycemic-hyperinsulinemic clamp and homeostasis model assessment insulin resistance index (HOMA-IR). Design and Setting: Evaluations were conducted before and 1 month after RYGBP at State University of Campinas (Sao Paulo, Brazil). Patients: Patients included 19 premenopausal women with metabolic syndrome aged 35.3 (6.7) yr, body mass index 45.50 (3.74) kg/m(2) {[}mean (SD)]. Six had mild type 2 diabetes, seven impaired glucose tolerance, and six normal glucose tolerance. Interventions and Main Outcome Measures: The volunteers underwent RYGBP either alone or combined with omentectomy. Euglycemic-hyperinsulinemic clamp, HOMA-IR, nonesterified fatty acids, leptin, ultrasensitive C-reactive protein, adiponectin, and IL-6 were assessed at baseline and 4.5 (0.9) wk postoperatively. Results: Fasting glucose decreased {[}99.2 (13.1) to 83.6 (8.1) mg/dl, P < 0.01] along with a reduction in fasting insulin {[}30.4 (17.0) to 11.4 (6.3) mU/liter, P < 0.01]. M value did not improve postoperatively {[}25.82 (6.30) to 22.02 (6.05) mu mol/kg(FFM) . min] despite of a decrease in body weight {[}114.8 (14.5) to 102.3 (14.5) kg, P < 0.001]. This finding was discordant to the observation of an improvement in HOMA-IR {[}3.85 (2.10) to 1.42 (0.76), P < 0.01]. Nonesterified fatty acids increased. Leptin and C-reactive protein decreased. IL-6 and adiponectin remained unchanged. Conclusions: A month after RYGBP, fasting glucose metabolism improves independent of a change in peripheral insulin sensitivity. (J Clin Endocrinol Metab 95: 3871-3875, 2010) (AU) | |
| Processo FAPESP: | 05/58627-2 - Efeitos da remoção cirúrgica de tecido adiposo visceral (omentectomia) sobre a sensibilidade à insulina em obesos grau III submetidos à cirurgia bariátrica |
| Beneficiário: | Bruno Geloneze Neto |
| Modalidade de apoio: | Auxílio à Pesquisa - Regular |