Micro-Positron Emission Tomography in the Evaluation of Trypanosoma cruzi-Induced Heart Disease: Comparison with Other Modalities

Autor(es)

Prado, Cibele M. ^[1] ; Fine, Eugene J. ^[2] ; Koba, Wade ^[2] ; Zhao, Dazhi ^[3] ; Rossi, Marcos A. ^[1] ; Tanowitz, Herbert B. ^[3] ; Jelicks, Linda A. ^[4]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Dept Pathol, Fac Med Ribeirao Preto, BR-14049900 Sao Paulo - Brazil

^[2] Albert Einstein Coll Med, M Donald Blaufox Lab Mol Imaging, Dept Med & Radiol, Bronx, NY 10461 - USA

^[3] Albert Einstein Coll Med, Dept Pathol, Bronx, NY 10461 - USA

^[4] Albert Einstein Coll Med, Dept Physiol & Biophys, Bronx, NY 10461 - USA

• Tipo de documento: Artigo Científico
• Fonte: American Journal of Tropical Medicine and Hygiene; v. 81, n. 5, p. 900-905, NOV 2009.
• Citações Web of Science: 17

Resumo

Noninvasive assessment of cardiac structure and function is essential to understand the natural course of murine infection with Trypanosoma cruzi. Magnetic resonance imaging (MRI) and echocardiography have been used to monitor anatomy and function; positron emission tomography (PET) is ideal for monitoring metabolic events in the myocardium. Mice infected with T. cruzi (Brazil strain) were imaged 15-100 days post infection (dpi). Quantitative (18)F-FDG microPET imaging, MRI and echocardiography were performed and compared. Tracer ((18)F-FDG) uptake was significantly higher in infected mice at all days of infection, from 15 to 100 dpi. Dilatation of the right ventricular chamber was observed by MRI from 30 to 100 dpi in infected mice. Echocardiography revealed significantly reduced ejection fraction by 60 dpi. Combination of these three complementary imaging modalities makes it possible to noninvasively quantify cardiovascular function, morphology, and metabolism from the earliest days of infection through the chronic phase. (AU)

• Processo FAPESP: 06/59618-0 - O possível papel do complexo de glicoproteínas associadas à distrofia na morte súbita na tripanossomiase americana experimental
• Beneficiário: Marcos Antonio Rossi
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 06/52882-3 - O possível papel do complexo de glicoproteínas associadas à distrofina na morte súbita na tripanosomíase americana experimental
• Beneficiário: Cibele Maria Prado Zinni
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 08/00954-6 - O possível papel do complexo de glicoproteínas associadas à distrofina e integrina na morte súbita na Doença de Chagas experimental
• Beneficiário: Cibele Maria Prado Zinni
• Modalidade de apoio: Bolsas no Exterior - Pesquisa