Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype

Autor(es)

Oliveira, Ana C. ^[1] ; Parise, Edison R. ^[1] ; Catarino, Regina M. ^[2] ; Lanzoni, Valeria ^[3] ; Leite-Mor, Mariliza M. B. ^[1] ; Simon, Karin Argenti ^[2] ; Junqueira, Virginia B. C. ^[2]

Afiliação do(s) autor(es)

^[1] Univ Fed Sao Paulo, Div Gastroenterol, Sao Paulo - Brazil

^[2] Univ Fed Sao Paulo, Dept Biol Sci, Sao Paulo - Brazil

^[3] Univ Fed Sao Paulo, Dept Pathol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Free Radical Research; v. 43, n. 12, p. 1187-1194, 2009.
• Citações Web of Science: 12

Resumo

Background: Modifications of oxidative stress are reported in hepatitis C. The relationship between insulin resistance (IR), steatosis and oxidative stress is not established. Materials and methods: One hundred and eighty-seven HCV-RNA patients were assessed by determination of biochemical, metabolic and viral features, HOMA-IR and morphological alterations. In the 52-non-3 genotypes sub-group and 35 healthy individuals, thiobarbituric acid (TBARS), total glutathione (total-GSH), vitamins C and E, lycopene, beta-carotene, glutathione peroxidase (GPx), catalase and superoxide dismutase were determined. Results: In non-3 genotype patients, steatosis was associated with higher values of BMI, HOMA-IR and triglycerides. In the 52-HCV sub-group, values of TBARS, GPx and total-GSH differ from the control group. Despite these, differences could not be observed according to the presence of steatosis, patients with IR presented significant differences regarding total-GSH (p = 0.019), beta-carotene (p = 0.006), lycopene (p = 0.005) and GPx (p = 0.009). Conclusion: In non-3 genotype HCV carries, IR, and not steatosis, is associated with modifications in serum levels of oxidative stress. (AU)

• Processo FAPESP: 02/05260-6 - Aspectos experimentais e clínicos da fibrose hepática e da hipertensão portal
• Beneficiário: Durval Rosa Borges
• Modalidade de apoio: Auxílio à Pesquisa - Temático