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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype

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Author(s):
Oliveira, Ana C. [1] ; Parise, Edison R. [1] ; Catarino, Regina M. [2] ; Lanzoni, Valeria [3] ; Leite-Mor, Mariliza M. B. [1] ; Simon, Karin Argenti [2] ; Junqueira, Virginia B. C. [2]
Total Authors: 7
Affiliation:
[1] Univ Fed Sao Paulo, Div Gastroenterol, Sao Paulo - Brazil
[2] Univ Fed Sao Paulo, Dept Biol Sci, Sao Paulo - Brazil
[3] Univ Fed Sao Paulo, Dept Pathol, Sao Paulo - Brazil
Total Affiliations: 3
Document type: Journal article
Source: Free Radical Research; v. 43, n. 12, p. 1187-1194, 2009.
Web of Science Citations: 12
Abstract

Background: Modifications of oxidative stress are reported in hepatitis C. The relationship between insulin resistance (IR), steatosis and oxidative stress is not established. Materials and methods: One hundred and eighty-seven HCV-RNA patients were assessed by determination of biochemical, metabolic and viral features, HOMA-IR and morphological alterations. In the 52-non-3 genotypes sub-group and 35 healthy individuals, thiobarbituric acid (TBARS), total glutathione (total-GSH), vitamins C and E, lycopene, beta-carotene, glutathione peroxidase (GPx), catalase and superoxide dismutase were determined. Results: In non-3 genotype patients, steatosis was associated with higher values of BMI, HOMA-IR and triglycerides. In the 52-HCV sub-group, values of TBARS, GPx and total-GSH differ from the control group. Despite these, differences could not be observed according to the presence of steatosis, patients with IR presented significant differences regarding total-GSH (p = 0.019), beta-carotene (p = 0.006), lycopene (p = 0.005) and GPx (p = 0.009). Conclusion: In non-3 genotype HCV carries, IR, and not steatosis, is associated with modifications in serum levels of oxidative stress. (AU)

FAPESP's process: 02/05260-6 - Experimental and clinical aspects of liver fibrosis and portal hypertension
Grantee:Durval Rosa Borges
Support Opportunities: Research Projects - Thematic Grants