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Experimental and clinical aspects of liver fibrosis and portal hypertension

Grant number: 02/05260-6
Support Opportunities:Research Projects - Thematic Grants
Duration: May 01, 2003 - November 30, 2007
Field of knowledge:Health Sciences - Medicine - Medical Clinics
Principal Investigator:Durval Rosa Borges
Grantee:Durval Rosa Borges
Host Institution: Escola Paulista de Medicina (EPM). Universidade Federal de São Paulo (UNIFESP). Campus São Paulo. São Paulo , SP, Brazil
Pesquisadores principais:
Angelo Paulo Ferrari Junior ; Edison Roberto Parise


The aim of the project is to study experimental and clinical aspects of tiver fibrosis and portal hypertension. Liver fibrosis Experimentally we will study: 1) the influence of age on the liver reaction to chemical aggression and inflammatory stimulus; 2) the liver effect of drugs (atorvastain and/or arnlodipin) administered with or without ethanol. Clinically we will study: 1) the role of co-infection (HBV and HIV) and fibrogenesis biochemical markers in the evolution of HCV chronic hepatitis; 2) the HCV core antigen in patients with chronic renal inefficiency; 3) the effect of UDCA in patients with the compensated and pure form of chronic schistosomiasis. Portal hypertension experimentally we will study the effects of bradykinin and angiotensin on portal responslveness. Clinically we will study: 1) platelet homeostasis in patients with the compensated and pure form of chronic schistosomiasis; 2) the role of echoendoscopy in the treatment of gastro-esophageal varices. (AU)

Articles published in Agência FAPESP Newsletter about the research grant:
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Scientific publications (4)
(References retrieved automatically from Web of Science and SciELO through information on FAPESP grants and their corresponding numbers as mentioned in the publications by the authors)
OLIVEIRA, ANA C.; PARISE, EDISON R.; CATARINO, REGINA M.; LANZONI, VALERIA; LEITE-MOR, MARILIZA M. B.; SIMON, KARIN ARGENTI; JUNQUEIRA, VIRGINIA B. C.. Insulin resistance and not steatosis is associated with modifications in oxidative stress markers in chronic hepatitis C, non-3 genotype. Free Radical Research, v. 43, n. 12, p. 1187-1194, . (02/05260-6)
PARISE‚ E.R.; OLIVEIRA‚ A.C.; FIGUEIREDO-MENDES‚ C.; LANZONI‚ V.; MARTINS‚ J.; NADER‚ H.; FERRAZ‚ M.L.. Noninvasive serum markers in the diagnosis of structural liver damage in chronic hepatitis C virus infection. LIVER INTERNATIONAL, v. 26, n. 9, p. 1095-1099, . (02/05260-6)
KOUYOUMDJIAN‚ M.; NAGAOKA‚ M.R.; BORGES‚ D.R.. Kallikrein-kinin system in hepatic experimental models. Peptides, v. 26, n. 8, p. 1301-1307, . (02/05260-6)
NASCIMENTO‚ É.A.; GIOLI-PEREIRA‚ L.; CARVALHO‚ L.T.; SANTOS‚ E.L.; PESQUERO‚ J.B.; KOUYOUMDJIAN‚ M.; BORGES‚ D.R.. Hemodynamic and metabolic effects of angiotensin II on the liver. Peptides, v. 26, n. 2, p. 315-322, . (02/05260-6)

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