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(Referência obtida automaticamente do Web of Science, por meio da informação sobre o financiamento pela FAPESP e o número do processo correspondente, incluída na publicação pelos autores.)

Longitudinal follow-up of cavum septum pellucidum and adhesio interthalamica alterations in first-episode psychosis: a population-based MRI study

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Autor(es):
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Trzesniak, C. [1, 2] ; Schaufelberger, M. S. [3] ; Duran, F. L. S. [3] ; Santos, L. C. [3] ; Rosa, P. G. P. [3] ; McGuire, P. K. [1] ; Murray, R. M. [1] ; Scazufca, M. [3] ; Menezes, P. R. [3] ; Hallak, J. E. C. [2] ; Crippa, J. A. S. [2] ; Busatto, G. F. [3]
Número total de Autores: 12
Afiliação do(s) autor(es):
[1] Kings Coll London, Inst Psychiat, Dept Psychosis Studies, London - England
[2] Univ Sao Paulo, Sch Med, Dept Neurosci & Behav Sci, Sao Paulo - Brazil
[3] Univ Sao Paulo, Fac Med, Dept & Inst Psychiat, BR-05508 Sao Paulo - Brazil
Número total de Afiliações: 3
Tipo de documento: Artigo Científico
Fonte: PSYCHOLOGICAL MEDICINE; v. 42, n. 12, p. 2523-2534, DEC 2012.
Citações Web of Science: 18
Resumo

Background. Neurodevelopmental alterations have been described inconsistently in psychosis probably because of lack of standardization among studies. The aim of this study was to conduct the first longitudinal and population-based magnetic resonance imaging (MRI) evaluation of the presence and size of the cavum septum pellucidum (CSP) and adhesio interthalamica (AI) in a large sample of patients with first-episode psychosis (FEP). Method. FEP patients (n=122) were subdivided into schizophrenia (n=62), mood disorders (n=46) and other psychosis (n=14) groups and compared to 94 healthy next-door neighbour controls. After 13 months, 80 FEP patients and 52 controls underwent a second MRI examination. Results. We found significant reductions in the AI length in schizophrenia FEP in comparison with the mood disorders and control subgroups (longer length) at the baseline assessment, and no differences in any measure of the CSP. By contrast, there was a diagnosis x time interaction for the CSP length, with a more prominent increase for this measure in the psychosis group. There was an involution of the AI length over time for all groups but no diagnosis x time interaction. Conclusions. Our findings suggest that the CSP per se may not be linked to the neurobiology of emerging psychotic disorders, although it might be related to the progression of the disease. However, the fact that the AI length was shown to be shorter at the onset of the disorder supports the neurodevelopmental model of schizophrenia and indicates that an alteration in this grey matter junction may be a risk factor for developing psychosis. (AU)

Processo FAPESP: 03/13627-0 - Seguimento de pacientes portadores de psicoses funcionais um ano após o primeiro contato com serviços de saúde: prognóstico, aspectos de neuroimagem, uso de serviços e sobrecarga em cuidadores informais
Beneficiário:Geraldo Busatto Filho
Linha de fomento: Auxílio à Pesquisa - Regular
Processo FAPESP: 08/57847-7 - Alterações de neurodesenvolvimento avaliadas por meio de ressonância magnética estrutural em pacientes em primeiro surto psicótico e em epilepsia
Beneficiário:Clarissa Maria Ferreira Trzesniak
Linha de fomento: Bolsas no Brasil - Doutorado