| Texto completo | |
| Autor(es): |
Queiroz, Julia de Souza
[1, 2, 3]
;
Torello, Cristiane Okuda
[1, 2]
;
Palermo-Neto, Joao
[3]
;
Valadares, Marize C.
[4]
;
Queiroz, Mary L. S.
[1, 2]
Número total de Autores: 5
|
| Afiliação do(s) autor(es): | [1] Univ Estadual Campinas, UNICAMP, Dept Farmacol, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Fac Ciencias Med, Hemoctr, BR-13083970 Campinas, SP - Brazil
[3] Univ Sao Paulo, Escola Med Vet, Lab Farmacol Aplicada & Toxicol, Sao Paulo - Brazil
[4] Univ Fed Goias, Fac Farm, Lab Farmacol & Toxicol Celular, Goiania, Go - Brazil
Número total de Afiliações: 4
|
| Tipo de documento: | Artigo Científico |
| Fonte: | BRAIN BEHAVIOR AND IMMUNITY; v. 22, n. 7, p. 1056-1065, Oct. 2008. |
| Área do conhecimento: | Ciências Biológicas - Farmacologia |
| Citações Web of Science: | 13 |
| Assunto(s): | Algas Chlorella vulgaris Bactérias Listeria monocytogenes Medula óssea Hematopoese |
| Resumo | |
In this study, we investigated the hematopoietic response of rats pretreated with CV and exposed to the impact of acute escapable, inescapable or psychogenical stress on responsiveness to an in vivo challenge with Listeria monocytogenes. No consistent changes were observed after exposure to escapable footshock. Conversely, the impact of uncontrollable stress (inescapable and psychogenical) was manifested by an early onset and increased severity and duration of myelossuppression produced by the infection. Small size CFU-GM colonies and increased numbers of clusters were observed, concurrently to a greater expansion in the more mature population of bone marrow granulocytes. No differences were observed between the responses of both uncontrollable stress regimens. CV prevented the myelossuppression caused by stress/infection due to increased numbers of CFU-GM in the bone marrow. Colonies of cells tightly packed, with a very condensed nucleus; in association with a greater expansion in the more immature population of bone marrow granulocytes were observed. Investigation of the production of colony-stimulating factors revealed increased colony-stimulating activity (CSA) in the serum of normal and infected/stressed rats treated with the algae. CV treatment restored/enhanced the changes produced by stress/infection in total and differential bone marrow and peripheral cells counts. Further studies demonstrated that INF-GAMMA is significantly reduced, whereas IL-10 is significantly increased after exposure to uncontrollable stress. Treatment with CV significantly increased INF-GAMMA levels and diminished the levels of IL-10. Uncontrollable stress reduced the protection afforded by CV to a lethal dose of L. monocytogenes, with survival rates being reduced from (50%) in infected rats to 20% in infected/stressed rats... (AU) | |
| Processo FAPESP: | 01/13823-8 - Alterações imunotoxicológicas e estresse oxidativo de eritrócitos e neutrófilos em trabalhadores expostos à silica |
| Beneficiário: | Mary Luci de Souza Queiroz |
| Modalidade de apoio: | Auxílio à Pesquisa - Temático |