Cyclosporin A causes impairment of the ventral pro... - BV FAPESP
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Cyclosporin A causes impairment of the ventral prostate tissue structure of Wistar rats

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Autor(es):
Freitas, K. M. [1] ; Monteiro, J. C. [2] ; Gomes, M. L. M. [3] ; Taboga, S. R. [4] ; Dolder, H. [1]
Número total de Autores: 5
Afiliação do(s) autor(es):
[1] Univ Campinas IB UNICAMP, Inst Biol, Dept Struct & Funct Biol, Campinas, SP - Brazil
[2] Univ Fed Espirito Santo, Dept Agron & Biol Sci, CEUNES, Sao Mateus - Brazil
[3] Univ Fed Espirito Santo, Dept Hlth Sci, CEUNES, Sao Mateus - Brazil
[4] Univ Sao Paulo, IBILCE State, Dept Biol, Sao Jose Do Rio Preto - Brazil
Número total de Afiliações: 4
Tipo de documento: Artigo Científico
Fonte: HUMAN & EXPERIMENTAL TOXICOLOGY; v. 31, n. 12, p. 1262-1270, DEC 2012.
Citações Web of Science: 5
Resumo

Cyclosporin A (CsA) is an immunosuppressive drug widely used in medicine to reduce the immune system activity and, therefore, the risk of organ rejection after transplantation. However, many side effects can be related to its use, such as, reduction in serum testosterone levels due to damage of the testis structure and, consequently, male infertility. The present study aims to evaluate the effects of chronic CsA administration on the ventral prostate tissue ( 1 5 mg/kg per d, for 56 days). Stereological, morphometrical, morphological and ultrastructural observations were employed. The plasmatic testosterone and glucose levels were measured. An androgen receptor (AR) immunohistochemical method was applied on ventral prostate sections. Apoptosis was detected with the terminal deoxynucleotidyl transferase dUTP nick end labeling technique. CsA treatment caused reduction in plasmatic testosterone levels and an increase in glycemia. The volume of all ventral prostate tissue components (lumen, epithelium and muscular and nonmuscular stroma) and ventral prostate weight were reduced in the CsA-treated group. Light and transmission electron microscopy confirmed epithelium atrophy of treated animals. There was no alteration of AR expression or apoptotic index. CsA chronic treatment in the therapeutic doses caused damage to prostate tissue of adult Wistar rats, probably due to increase in the glucose levels and reduction in the plasmatic testosterone levels. (AU)

Processo FAPESP: 09/07824-3 - Efeito da ciclosporina A associada à infusão de nó-de-cachorro (Heteropterys aphrodisiaca, O. Mach, 1949) na próstata de ratos Wistar
Beneficiário:Karine Moura de Freitas
Modalidade de apoio: Bolsas no Brasil - Mestrado