Clinical impact of an angiotensin I-converting enzyme insertion/deletion and kinin B2 receptor +9/-9 polymorphisms in the prognosis of renal transplantation

Autor(es)

Amorim, Carlos E. N. ^[1] ; Nogueira, Eliana ^[2] ; Almeida, Sandro S. ^[1] ; Gomes, Pedro P. G. ^[1] ; Bacurau, Reury F. P. ^[3] ; Suzete Ozaki, K. ^[2] ; Cenedeze, Marcos A. ^[2] ; Silva Filho, Alvaro P. ^{[4, 2]} ; Camara, Niels O. S. ^{[2, 5]} ; Araujo, Ronaldo C. ^[1]

Afiliação do(s) autor(es)

^[1] Fed Univ Sao Paulo UNIFESP, Dept Biophys, Sao Paulo - Brazil

^[2] Fed Univ Sao Paulo UNIFESP, Lab Clin & Expt Immunol, Div Nephrol, Sao Paulo - Brazil

^[3] Univ Sao Paulo, Sch Arts Sci & Humanities, Sao Paulo - Brazil

^[4] Hosp Israelita Albert Einstein, IIEP, Sao Paulo - Brazil

^[5] Univ Sao Paulo, Lab Transplantat Immunobiol, Dept Immunol, Inst Biomed Sci 4, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Biological Chemistry; v. 394, n. 3, p. 369-377, MAR 2013.
• Citações Web of Science: 5

Resumo

There is a consensus in the scientific literature that supports the importance of the kallikrein kinin and renin angiotensin systems in renal physiology, but few studies have investigated their importance after renal transplantation. The aim of this study was to investigate the clinical effects of the insertion/deletion polymorphism in the angiotensin I-converting enzyme (ACE) gene and the +9/-9 polymorphism in the kinin B2 receptor (B2R) gene in kidney-transplanted patients (n=215 ACE, n=203 B2R) compared with 443 healthy individuals. Demographic results showed that there is a higher frequency of the D allele (high plasma ACE activity) and +9 allele (lower B2R expression) in transplant patients compared with control individuals. We also observed a higher frequency of these alleles in patients who had an elevated level of plasma creatinine. At day 7 post-transplantation, we found a higher prevalence of individuals with the DD genotype with elevated plasma creatinine level. Furthermore, individuals with the DD genotype had a higher chronic allograft dysfunction and graft loss compared with the II patient genotype, which showed no loss of graft. Taken together, our data suggest that the DD genotype is an indicator of an unfavorable prognosis following renal transplantation and could be related to kinin modulation. (AU)

• Processo FAPESP: 10/52180-4 - Fisiopatologia e regeneração das lesões renais
• Beneficiário: Nestor Schor
• Linha de fomento: Auxílio à Pesquisa - Temático
• Processo FAPESP: 12/02270-2 - Novos mecanismos celulares, moleculares e imunológicos das lesões renais agudas e crônicas: busca por novas estratégias terapêuticas
• Beneficiário: Niels Olsen Saraiva Câmara
• Linha de fomento: Auxílio à Pesquisa - Temático