Discriminating sarcopenia in community-dwelling older women with high frequency of overweight/obesity: the So Paulo Ageing & Health Study (SPAH)

Autor(es)

Domiciano, D. S. ^[1] ; Figueiredo, C. P. ^[1] ; Lopes, J. B. ^[1] ; Caparbo, V. F. ^[1] ; Takayama, L. ^[1] ; Menezes, P. R. ^[2] ; Bonfa, E. ^[1] ; Pereira, R. M. R. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Bone Metab Lab, Div Rheumatol, Fac Med, BR-01246903 Sao Paulo - Brazil

^[2] Univ Sao Paulo, Dept Prevent Med, Fac Med, BR-01246903 Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: OSTEOPOROSIS INTERNATIONAL; v. 24, n. 2, p. 595-603, FEB 2013.
• Citações Web of Science: 26

Resumo

The criteria most used for the definition of sarcopenia, those based on the ratio between the appendicular skeletal muscle mass (ASM) and the square of the height (h(2)) underestimate prevalence in overweight/obese people whereas another criteria consider ASM adjusted for total fat mass. We have shown that ASM adjusted for fat seems to be more appropriate for sarcopenia diagnosis. Since the prevalence of overweight and obesity is a growing public health issue, the aim of this study was to evaluate the prevalence and risk factors associated with sarcopenia, based on these two criteria, among older women. Six hundred eleven community-dwelling women were evaluated by specific questionnaire including clinical data. Body composition and bone mineral density were evaluated by dual X-ray absorptiometry. Logistic regression models were used to identify factors independently related to sarcopenia by ASM/h(2) and ASM adjusted for total fat mass criteria. The prevalence of overweight/obesity was high (74.3 %). The frequency of sarcopenia was lower using the criteria of ASM/h(2) (3.7 %) than ASM adjusted for fat (19.9 %) (P < 0.0001). We also note that less than 5 %(1/23) of sarcopenic women, according to ASM/h(2), had overweight/obesity, whereas 60 % (74/122) of sarcopenic women by ASM adjusted for fat had this complication. Using ASM/h(2), the associated factors observed in regression models were femoral neck T-score (OR = 1.90; 95 % CI 1.06-3.41; P = 0.03) and current alcohol intake (OR = 4.13, 95 % CI 1.18-14.45, P = 0.03). In contrast, we have identified that creatinine (OR = 0.21; 95 % CI 0.07-0.63; P = 0.005) and the White race (OR = 1.81; 95 % CI 1.15-2.84; P = 0.01) showed a significant association with sarcopenia using ASM adjusted for fat. In women with overweight/obesity, ASM adjusted for fat seems to be the more appropriate criteria for sarcopenia diagnosis. This finding has relevant public health implications, considering the high prevalence of overweight/obesity in older women. (AU)

• Processo FAPESP: 03/09313-0 - Prevalência de osteoporose, fraturas vertebrais e não vertebrais em uma população feminina, de 65 anos ou mais na área do Butantã
• Beneficiário: Rosa Maria Rodrigues Pereira
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 04/12694-8 - Incidência de demência e declínio cognitivo em idosos de baixa renda em São Paulo: estudo de coorte
• Beneficiário: Isabela Judith Martins Bensenor
• Modalidade de apoio: Auxílio à Pesquisa - Regular