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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Discriminating sarcopenia in community-dwelling older women with high frequency of overweight/obesity: the So Paulo Ageing & Health Study (SPAH)

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Author(s):
Domiciano, D. S. [1] ; Figueiredo, C. P. [1] ; Lopes, J. B. [1] ; Caparbo, V. F. [1] ; Takayama, L. [1] ; Menezes, P. R. [2] ; Bonfa, E. [1] ; Pereira, R. M. R. [1]
Total Authors: 8
Affiliation:
[1] Univ Sao Paulo, Bone Metab Lab, Div Rheumatol, Fac Med, BR-01246903 Sao Paulo - Brazil
[2] Univ Sao Paulo, Dept Prevent Med, Fac Med, BR-01246903 Sao Paulo - Brazil
Total Affiliations: 2
Document type: Journal article
Source: OSTEOPOROSIS INTERNATIONAL; v. 24, n. 2, p. 595-603, FEB 2013.
Web of Science Citations: 26
Abstract

The criteria most used for the definition of sarcopenia, those based on the ratio between the appendicular skeletal muscle mass (ASM) and the square of the height (h(2)) underestimate prevalence in overweight/obese people whereas another criteria consider ASM adjusted for total fat mass. We have shown that ASM adjusted for fat seems to be more appropriate for sarcopenia diagnosis. Since the prevalence of overweight and obesity is a growing public health issue, the aim of this study was to evaluate the prevalence and risk factors associated with sarcopenia, based on these two criteria, among older women. Six hundred eleven community-dwelling women were evaluated by specific questionnaire including clinical data. Body composition and bone mineral density were evaluated by dual X-ray absorptiometry. Logistic regression models were used to identify factors independently related to sarcopenia by ASM/h(2) and ASM adjusted for total fat mass criteria. The prevalence of overweight/obesity was high (74.3 %). The frequency of sarcopenia was lower using the criteria of ASM/h(2) (3.7 %) than ASM adjusted for fat (19.9 %) (P < 0.0001). We also note that less than 5 %(1/23) of sarcopenic women, according to ASM/h(2), had overweight/obesity, whereas 60 % (74/122) of sarcopenic women by ASM adjusted for fat had this complication. Using ASM/h(2), the associated factors observed in regression models were femoral neck T-score (OR = 1.90; 95 % CI 1.06-3.41; P = 0.03) and current alcohol intake (OR = 4.13, 95 % CI 1.18-14.45, P = 0.03). In contrast, we have identified that creatinine (OR = 0.21; 95 % CI 0.07-0.63; P = 0.005) and the White race (OR = 1.81; 95 % CI 1.15-2.84; P = 0.01) showed a significant association with sarcopenia using ASM adjusted for fat. In women with overweight/obesity, ASM adjusted for fat seems to be the more appropriate criteria for sarcopenia diagnosis. This finding has relevant public health implications, considering the high prevalence of overweight/obesity in older women. (AU)

FAPESP's process: 03/09313-0 - Prevalence of osteoporosis, vertebral and non-vertebral fractures in a female population aged 65 or older in the Butantã area
Grantee:Rosa Maria Rodrigues Pereira
Support Opportunities: Regular Research Grants
FAPESP's process: 04/12694-8 - Incidence of dementia and cognitive decline in low-income elderly in São Paulo: a cohort study
Grantee:Isabela Judith Martins Bensenor
Support Opportunities: Regular Research Grants