The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats

Autor(es)

Fernandes de Azevedo, Vera Lucia ^[1] ; Santana Santos, Paulo Sergio ^[1] ; de Oliveira, Jr., Gildasio Silveira ^[2] ; Modolo, Gabriel Pinheiro ^[3] ; Custodio Domingues, Maria Aparecida ^[4] ; Machado Castiglia, Yara Marcondes ^[5] ; Galvao Vianna, Pedro Thadeu ^[5] ; Vane, Luiz Antonio ^[5] ; Pinheiro Modolo, Norma Sueli ^[5]

Afiliação do(s) autor(es)

^[1] Univ Estadual Paulista, Botucatu Med Sch, Postgrad Program Anesthesiol, Sao Paulo - Brazil

^[2] Northwestern Univ, Feinberg Sch Med, Dept Anesthesiol, Chicago, IL 60611 - USA

^[3] Santa Casa Fac Med Sao Paulo, Sao Paulo - Brazil

^[4] Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Sao Paulo - Brazil

^[5] Univ Estadual Paulista, Botucatu Med Sch, Dept Anesthesiol, Sao Paulo - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Acta Cirurgica Brasileira; v. 28, n. 1, p. 5-9, JAN 2013.
• Citações Web of Science: 6

Resumo

PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml.kg-1.hr-1or RL 5 ml. kg-1.hr-1 that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion. (AU)

• Processo FAPESP: 10/08562-0 - NGAL como marcador precoce de lesão em ratos submetidos à isquemia renal sob anestesia geral balanceada, hidratados com Ringer lactato ou amido: comparação com critério de Rifle
• Beneficiário: Norma Sueli Pinheiro Módolo
• Modalidade de apoio: Auxílio à Pesquisa - Regular