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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

The effect of 6% Hydroxyethyl starch vs. Ringer's lactate on acute kidney injury after renal ischemia in rats

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Fernandes de Azevedo, Vera Lucia [1] ; Santana Santos, Paulo Sergio [1] ; de Oliveira, Jr., Gildasio Silveira [2] ; Modolo, Gabriel Pinheiro [3] ; Custodio Domingues, Maria Aparecida [4] ; Machado Castiglia, Yara Marcondes [5] ; Galvao Vianna, Pedro Thadeu [5] ; Vane, Luiz Antonio [5] ; Pinheiro Modolo, Norma Sueli [5]
Total Authors: 9
[1] Univ Estadual Paulista, Botucatu Med Sch, Postgrad Program Anesthesiol, Sao Paulo - Brazil
[2] Northwestern Univ, Feinberg Sch Med, Dept Anesthesiol, Chicago, IL 60611 - USA
[3] Santa Casa Fac Med Sao Paulo, Sao Paulo - Brazil
[4] Univ Estadual Paulista, Botucatu Med Sch, Dept Pathol, Sao Paulo - Brazil
[5] Univ Estadual Paulista, Botucatu Med Sch, Dept Anesthesiol, Sao Paulo - Brazil
Total Affiliations: 5
Document type: Journal article
Source: Acta Cirurgica Brasileira; v. 28, n. 1, p. 5-9, JAN 2013.
Web of Science Citations: 6

PURPOSE: To compare fluid replacement therapy with Hydroxyethyl starch 6% (HES) versus Ringer's lactate (RL) in a rodent model of non-septic renal ischemia. METHODS: Forty male Wistar rats were randomized to receive HES 2 ml. kg(-1).hr(-1) or RL 5 ml. kg(-1).hr(-1) that underwent 30 minutes of renal ischemia followed by reperfusion. Twelve hours after kidney ischemia, the kidneys were evaluated for histological changes. Serum NGAL levels were obtained at different times of the experimental protocol. RESULTS: Rodents in the HES group had a median (IQR) grade of renal injury 3 (3 to 5) compared to 2 (2 to 4) in the RL group (p=0.03). NGAL levels were not associated with the severity of kidney injury. CONCLUSION: Hydroxyethyl starch administration caused more kidney injury than Ringer's lactate in a non-infectious model of renal hypoperfusion. (AU)

FAPESP's process: 10/08562-0 - Ngal as a biomarker of acute kidney injury in rats undergoing balanced anesthesia - influence of fluid resuscitation with Ringer lactate or hydroxyethyl starch: comparative assessment of the Rifle criteria
Grantee:Norma Sueli Pinheiro Módolo
Support type: Regular Research Grants