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NGAL as a biomarker of acute kidney injury in rats undergoing balanced anesthesia - influence of fluid resuscitation with Ringer Lactate or hydroxyethyl starch: comparative assessment of the Rifle criteria

Grant number: 10/12862-9
Support type:Scholarships in Brazil - Scientific Initiation
Effective date (Start): November 01, 2010
Effective date (End): October 31, 2011
Field of knowledge:Health Sciences - Medicine - Surgery
Principal researcher:Norma Sueli Pinheiro Módolo
Grantee:Gustavo Iacomini Ida
Home Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


20 Wistar rats weighing 250-300 grams are anesthetized with isoflurane and remifentanil by continuous infusion to achieve D nephrectomy and renal artery clamping and for a period of 30 minutes. The animals will be divided into two study groups according to volume replacement performed: Ringer's lactate or starch hidroxietil. Blood samples taken before performing nephrectomy and renal ischemia after releasing the clamp, after 30 minutes and postoperative immediately for assay of creatinine and NGAL. These doses will be compared to the criterion of Rifle. (AU)

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