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NGAL as a biomarker of acute kidney injury in rats undergoing total intravenous anesthesia: influence of fluid resuscitation with Ringer lactate or hydroxyethyl starch: comparative assessment of tha RIFLE criteria

Grant number: 10/08900-2
Support Opportunities:Regular Research Grants
Duration: December 01, 2010 - February 29, 2012
Field of knowledge:Health Sciences - Medicine - Surgery
Principal Investigator:Norma Sueli Pinheiro Módolo
Grantee:Norma Sueli Pinheiro Módolo
Host Institution: Faculdade de Medicina (FMB). Universidade Estadual Paulista (UNESP). Campus de Botucatu. Botucatu , SP, Brazil


20 Wistar rats weighing 250-300 grams are anesthetized with propofol and remifentanil by continuous infusion to achieve D nephrectomy and renal artery clamping and for a period of 30 minutes. The animals will be divided into two study groups according to volume replacement performed: Ringer's lactate or hydroxyethyl starch. Blood samples taken before the completion of nephrectomy and renal ischemia after releasing the clamp, 30 minutes and in the immediate postoperative period for assay of creatinine and NGAL. These doses will be compared to the criterion of Rifle. (AU)

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