Conducting polymer- hydrogel blends for electrochemically controlled drug release devices

Autor(es)

Rosângela C. Barthus ^[1] ; Luiz M. Lira ^[2] ; Susana I. Córdoba de Torresi ^[3]

Afiliação do(s) autor(es)

^[1] Universidade de São Paulo. Instituto de Química - Brasil

^[2] Universidade de São Paulo. Instituto de Química - Brasil

^[3] Universidade de São Paulo. Instituto de Química - Brasil

• Tipo de documento: Artigo Científico
• Fonte: Journal of the Brazilian Chemical Society; v. 19, n. 4, p. 630-636, 2008-00-00.

Resumo

Blends formed by electrochemical polymerization of polypyrrole (PPy) into polyacrylamide (PAAm) hydrogels were used as devices for controlled drug release. The influence of several parameters in the synthesis, such as type of hydrogel matrix and polymerization conditions was studied by using a fractional factorial design. The final goal was to obtain an adequate device for use in controlled release tests, based on electrochemical potential control. For controlled release tests, Safranin was used as model drug and release curves (amount of drug vs. time) have shown that these blends are promising materials for this use. The optimized blends obtained were characterized by cyclic voltammetry and Raman spectroscopy. (AU)

• Processo FAPESP: 03/10015-3 - Arranjos organizados de macromoléculas e nanoestruturas para o desenvolvimento de sensores e microbaterias
• Beneficiário: Roberto Manuel Torresi
• Modalidade de apoio: Auxílio à Pesquisa - Programa PRONEX - Temático