| Full text | |
| Author(s): |
Total Authors: 3
|
| Affiliation: | [1] Universidade de São Paulo. Instituto de Química - Brasil
[2] Universidade de São Paulo. Instituto de Química - Brasil
[3] Universidade de São Paulo. Instituto de Química - Brasil
Total Affiliations: 3
|
| Document type: | Journal article |
| Source: | Journal of the Brazilian Chemical Society; v. 19, n. 4, p. 630-636, 2008-00-00. |
| Abstract | |
Blends formed by electrochemical polymerization of polypyrrole (PPy) into polyacrylamide (PAAm) hydrogels were used as devices for controlled drug release. The influence of several parameters in the synthesis, such as type of hydrogel matrix and polymerization conditions was studied by using a fractional factorial design. The final goal was to obtain an adequate device for use in controlled release tests, based on electrochemical potential control. For controlled release tests, Safranin was used as model drug and release curves (amount of drug vs. time) have shown that these blends are promising materials for this use. The optimized blends obtained were characterized by cyclic voltammetry and Raman spectroscopy. (AU) | |
| FAPESP's process: | 03/10015-3 - Organized arrays of macromolecules and nanostructures for the development of sensors and microbatteries |
| Grantee: | Roberto Manuel Torresi |
| Support Opportunities: | PRONEX Research - Thematic Grants |