Reduced Serum Nerve Growth Factor in Patients With Late-Life Depression

Autor(es)

Diniz, Breno S. ^{[1, 2]} ; Teixeira, Antonio L. ^{[3, 4]} ; Machado-Vieira, Rodrigo ^[1] ; Talib, Leda L. ^[1] ; Gattaz, Wagner F. ^[1] ; Forienza, Orestes V. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Med, Dept & Inst Psychiat, BR-05403010 Sao Paulo - Brazil

^[2] Univ Fed Minas Gerais, Dept Mental Hlth, Sch Med, Lab Neurosci LIM 27, Belo Horizonte, MG - Brazil

^[3] Univ Fed Minas Gerais, Grp Neuroimmunol, Lab Immunopharmacol, Inst Biol Sci, Belo Horizonte, MG - Brazil

^[4] Univ Fed Minas Gerais, Sch Med, Belo Horizonte, MG - Brazil

• Tipo de documento: Artigo Científico
• Fonte: AMERICAN JOURNAL OF GERIATRIC PSYCHIATRY; v. 21, n. 5, p. 493-496, MAY 2013.
• Citações Web of Science: 36

Resumo

Introduction: Nerve growth factor (NGF) is one of the most abundant neurotrophic factors in the central nervous system and has been involved in several neuropsychiatric disorders. Methods: We recruited 77 age- and gender-matched elderly subjects (38 with late-life depression, 17 with previous major depressive episode, and 22 healthy subjects in the comparison group). Serum concentration of NGF was determined by enzyme-linked immunosorbent assay. Results: NGF levels were significantly reduced in the depressed patients (p = 0.002) as compared with healthy elderly controls. Elderly control subjects with previous depressive episode also showed a significant reduction in NGF levels as compared with controls (p <0.01); NGF levels were similar between patients with current depressive episode and previous depressive episode (p = 0.2). Conclusion: The present findings provide additional evidence to the relevance of reduced neurotrophic support in the pathophysiology of late-life depression. Also, reduced serum NGF level may be a state marker of depression in elderly subjects. (Am J Geriatr Psychiatry 2013; 21:493-496) (AU)

• Processo FAPESP: 09/52825-8 - Neurobiologia da doença de Alzheimer: marcadores de risco, prognóstico e resposta terapêutica
• Beneficiário: Wagner Farid Gattaz
• Modalidade de apoio: Auxílio à Pesquisa - Temático