Study of a series of cobalt(II) sulfonamide complexes: Synthesis, spectroscopic characterization, and microbiological evaluation against M. tuberculosis. Crystal structure of [Co( sulfamethoxazole)(2)(H2O)(2)]center dot H2O

Autor(es)

Mondelli, Melina ^[1] ; Pavan, Fernando ^[2] ; de Souza, Paula C. ^[2] ; Leite, Clarice Q. ^[2] ; Ellena, Javier ^[3] ; Nascimento, Otaciro R. ^[4] ; Facchin, Gianella ^[1] ; Torre, Maria H. ^[1]

Afiliação do(s) autor(es)

^[1] UDELAR, Fac Quim, Quim Inorgan DEC, Montevideo - Uruguay

^[2] UNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil

^[3] Univ Sao Paulo, Inst Fis Sao Carlos, Lab Cristalog, BR-13560 Sao Carlos, SP - Brazil

^[4] Univ Sao Paulo, Inst Fis Sao Carlos, Grp Biofis Sergio Mascarenhas, BR-13560 Sao Carlos, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Molecular Structure; v. 1036, p. 180-187, MAR 27 2013.
• Citações Web of Science: 25

Resumo

Nowadays, the research for new and better antimicrobial compounds is an important field due to the increase of immunocompromised patients, the use of invasive medical procedures and extensive surgeries, among others, that can affect the incidence of infections. Another big problem associated is the occurrence of drug-resistant microbial strains that impels a ceaseless search for new antimicrobial agents. In this context, a series of heterocyclic-sulfonamide complexes with Co(II) was synthesized and characterized with the aim of obtaining new antimicrobial compounds. The structural characterization was performed using different spectroscopic methods (UV-Vis, IR, and EPR). In spite of the fact that the general stoichiometry for all the complexes was Co(sulfonamide)(2)center dot nH(2)O, the coordination atoms were different depending on the coordinated sulfonamide. The crystal structure of {[}Co(sulfamethoxazole)(2)(H2O)(2)]center dot H2O was obtained by X-ray diffraction showing that Co(II) is in a slightly tetragonal distorted octahedron where sulfamethoxazole molecules act as a head-to-tail bridges between two cobalt atoms, forming polymeric chains. Besides, the activity against Mycobacterium tuberculosis, one of the responsible for tuberculosis, and the cytotoxicity on J774A.1 macrophage cells were evaluated. (C) 2012 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 11/11593-7 - Pesquisa de novos fármacos contra tuberculose: implementação laboratorial para realizar ensaios pré-clínicos
• Beneficiário: Fernando Rogério Pavan
• Modalidade de apoio: Bolsas no Brasil - Pós-Doutorado
• Processo FAPESP: 09/06499-1 - Determinação da atividade anti-tuberculose in vitro e in vivo de complexos de Ru(II) fosfinas/diiminas
• Beneficiário: Clarice Queico Fujimura Leite
• Modalidade de apoio: Auxílio à Pesquisa - Regular