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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Study of a series of cobalt(II) sulfonamide complexes: Synthesis, spectroscopic characterization, and microbiological evaluation against M. tuberculosis. Crystal structure of [Co( sulfamethoxazole)(2)(H2O)(2)]center dot H2O

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Mondelli, Melina [1] ; Pavan, Fernando [2] ; de Souza, Paula C. [2] ; Leite, Clarice Q. [2] ; Ellena, Javier [3] ; Nascimento, Otaciro R. [4] ; Facchin, Gianella [1] ; Torre, Maria H. [1]
Total Authors: 8
[1] UDELAR, Fac Quim, Quim Inorgan DEC, Montevideo - Uruguay
[2] UNESP, Fac Ciencias Farmaceut, BR-14801902 Araraquara, SP - Brazil
[3] Univ Sao Paulo, Inst Fis Sao Carlos, Lab Cristalog, BR-13560 Sao Carlos, SP - Brazil
[4] Univ Sao Paulo, Inst Fis Sao Carlos, Grp Biofis Sergio Mascarenhas, BR-13560 Sao Carlos, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Molecular Structure; v. 1036, p. 180-187, MAR 27 2013.
Web of Science Citations: 25

Nowadays, the research for new and better antimicrobial compounds is an important field due to the increase of immunocompromised patients, the use of invasive medical procedures and extensive surgeries, among others, that can affect the incidence of infections. Another big problem associated is the occurrence of drug-resistant microbial strains that impels a ceaseless search for new antimicrobial agents. In this context, a series of heterocyclic-sulfonamide complexes with Co(II) was synthesized and characterized with the aim of obtaining new antimicrobial compounds. The structural characterization was performed using different spectroscopic methods (UV-Vis, IR, and EPR). In spite of the fact that the general stoichiometry for all the complexes was Co(sulfonamide)(2)center dot nH(2)O, the coordination atoms were different depending on the coordinated sulfonamide. The crystal structure of {[}Co(sulfamethoxazole)(2)(H2O)(2)]center dot H2O was obtained by X-ray diffraction showing that Co(II) is in a slightly tetragonal distorted octahedron where sulfamethoxazole molecules act as a head-to-tail bridges between two cobalt atoms, forming polymeric chains. Besides, the activity against Mycobacterium tuberculosis, one of the responsible for tuberculosis, and the cytotoxicity on J774A.1 macrophage cells were evaluated. (C) 2012 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 09/06499-1 - Determination of in vitro and in vivo anti-tuberculosis activity of phosphines/diimines Ru (II) complexes
Grantee:Clarice Queico Fujimura Leite
Support type: Regular Research Grants
FAPESP's process: 11/11593-7 - Research for new drugs against tuberculosis: laboratory improvement to perform pre-clinical trials
Grantee:Fernando Rogério Pavan
Support type: Scholarships in Brazil - Post-Doctorate