Synthesis, spectroscopic characterization, DFT studies, and antibacterial and antitumor activities of a novel water soluble Pd(II) complex with L-alliin

Autor(es)

Abbehausen, Camilla ^[1] ; Sucena, Suelen F. ^[1] ; Lancellotti, Marcelo ^[2] ; Heinrich, Tassiele A. ^[3] ; Abrao, Emiliana P. ^[3] ; Costa-Neto, Claudio M. ^[3] ; Formiga, Andre L. B. ^[4] ; Corbi, Pedro P. ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Bioinorgan & Med Chem Res Lab, LIQI, BR-13083970 Campinas, SP - Brazil

^[2] Univ Estadual Campinas, UNICAMP, Inst Biol, Biotechnol Lab, BR-13083970 Campinas, SP - Brazil

^[3] Univ Sao Paulo, USP, Sch Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, SP - Brazil

^[4] Univ Estadual Campinas, Inst Chem, Coordinat Chem Lab, LIQI, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: Journal of Molecular Structure; v. 1035, p. 421-426, MAR 13 2013.
• Citações Web of Science: 8

Resumo

A new water soluble Pd(II) complex with L-alliin (S-allyl-L-cysteine sulfoxide) was obtained and characterized by a set of chemical and spectroscopic measurements. Elemental and mass spectrometric data are consistent with the formula {[}Pd(C6H10NO3S)(2)]. The H-1 and C-13 nuclear magnetic resonance (NMR) data, {[}H-1-N-15] two dimensional (2D) NMR and infrared spectroscopic measurements indicate coordination of the ligand to Pd(II) through N and O atoms. DFT studies showed that the trans isomer is the most stable and preferred geometry for the complex. The complex is soluble in water and dimethylsulfoxide. An anti-biogram assay revealed that the complex possess antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus bacterial strains in the range 125-500 mu g mL(-1). Antitumor assays revealed that the complex presents cytotoxic activity over HeLa cells with an estimated IC50 of 20 mu mol L-1. (c) 2012 Elsevier B.V. All rights reserved. (AU)

• Processo FAPESP: 12/08230-2 - Síntese, caracterização e estudo das atividades farmacológicas de complexos metálicos de Ag(I), Au(I), Pt(II) e Pd(II) com ligantes bioativos
• Beneficiário: Pedro Paulo Corbi
• Modalidade de apoio: Auxílio à Pesquisa - Regular