| Full text | |
| Author(s): |
Abbehausen, Camilla
[1]
;
Sucena, Suelen F.
[1]
;
Lancellotti, Marcelo
[2]
;
Heinrich, Tassiele A.
[3]
;
Abrao, Emiliana P.
[3]
;
Costa-Neto, Claudio M.
[3]
;
Formiga, Andre L. B.
[4]
;
Corbi, Pedro P.
[1]
Total Authors: 8
|
| Affiliation: | [1] Univ Estadual Campinas, UNICAMP, Inst Chem, Bioinorgan & Med Chem Res Lab, LIQI, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Inst Biol, Biotechnol Lab, BR-13083970 Campinas, SP - Brazil
[3] Univ Sao Paulo, USP, Sch Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Estadual Campinas, Inst Chem, Coordinat Chem Lab, LIQI, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | Journal of Molecular Structure; v. 1035, p. 421-426, MAR 13 2013. |
| Web of Science Citations: | 8 |
| Abstract | |
A new water soluble Pd(II) complex with L-alliin (S-allyl-L-cysteine sulfoxide) was obtained and characterized by a set of chemical and spectroscopic measurements. Elemental and mass spectrometric data are consistent with the formula {[}Pd(C6H10NO3S)(2)]. The H-1 and C-13 nuclear magnetic resonance (NMR) data, {[}H-1-N-15] two dimensional (2D) NMR and infrared spectroscopic measurements indicate coordination of the ligand to Pd(II) through N and O atoms. DFT studies showed that the trans isomer is the most stable and preferred geometry for the complex. The complex is soluble in water and dimethylsulfoxide. An anti-biogram assay revealed that the complex possess antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus bacterial strains in the range 125-500 mu g mL(-1). Antitumor assays revealed that the complex presents cytotoxic activity over HeLa cells with an estimated IC50 of 20 mu mol L-1. (c) 2012 Elsevier B.V. All rights reserved. (AU) | |
| FAPESP's process: | 12/08230-2 - Synthesis, characterization and pharmacological studies of Ag(I), Au(I), Pt(II) and Pd(II) complexes with bioactive ligands |
| Grantee: | Pedro Paulo Corbi |
| Support Opportunities: | Regular Research Grants |