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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Synthesis, spectroscopic characterization, DFT studies, and antibacterial and antitumor activities of a novel water soluble Pd(II) complex with L-alliin

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Author(s):
Abbehausen, Camilla [1] ; Sucena, Suelen F. [1] ; Lancellotti, Marcelo [2] ; Heinrich, Tassiele A. [3] ; Abrao, Emiliana P. [3] ; Costa-Neto, Claudio M. [3] ; Formiga, Andre L. B. [4] ; Corbi, Pedro P. [1]
Total Authors: 8
Affiliation:
[1] Univ Estadual Campinas, UNICAMP, Inst Chem, Bioinorgan & Med Chem Res Lab, LIQI, BR-13083970 Campinas, SP - Brazil
[2] Univ Estadual Campinas, UNICAMP, Inst Biol, Biotechnol Lab, BR-13083970 Campinas, SP - Brazil
[3] Univ Sao Paulo, USP, Sch Med Ribeirao Preto, Dept Biochem & Immunol, BR-14049900 Ribeirao Preto, SP - Brazil
[4] Univ Estadual Campinas, Inst Chem, Coordinat Chem Lab, LIQI, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 4
Document type: Journal article
Source: Journal of Molecular Structure; v. 1035, p. 421-426, MAR 13 2013.
Web of Science Citations: 8
Abstract

A new water soluble Pd(II) complex with L-alliin (S-allyl-L-cysteine sulfoxide) was obtained and characterized by a set of chemical and spectroscopic measurements. Elemental and mass spectrometric data are consistent with the formula {[}Pd(C6H10NO3S)(2)]. The H-1 and C-13 nuclear magnetic resonance (NMR) data, {[}H-1-N-15] two dimensional (2D) NMR and infrared spectroscopic measurements indicate coordination of the ligand to Pd(II) through N and O atoms. DFT studies showed that the trans isomer is the most stable and preferred geometry for the complex. The complex is soluble in water and dimethylsulfoxide. An anti-biogram assay revealed that the complex possess antibacterial activity against Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus bacterial strains in the range 125-500 mu g mL(-1). Antitumor assays revealed that the complex presents cytotoxic activity over HeLa cells with an estimated IC50 of 20 mu mol L-1. (c) 2012 Elsevier B.V. All rights reserved. (AU)

FAPESP's process: 12/08230-2 - Synthesis, characterization and pharmacological studies of Ag(I), Au(I), Pt(II) and Pd(II) complexes with bioactive ligands
Grantee:Pedro Paulo Corbi
Support Opportunities: Regular Research Grants