Epilepsy as progressive disorders: What is the evidence that can guide our clinical decisions and how can neuroimaging help?

Autor(es)

Coan, Ana C. ^[1] ; Cendes, Fernando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Neuroimaging Lab, Dept Neurol, BR-13083970 Campinas, SP - Brazil

• Tipo de documento: Artigo de Revisão
• Fonte: Epilepsy & Behavior; v. 26, n. 3, p. 313-321, MAR 2013.
• Citações Web of Science: 13

Resumo

There is evidence that some types of epilepsy progress over time, and an important part of this knowledge has derived from neuroimaging studies. Different authors have demonstrated structural damage more pronounced in individuals with a longer duration of epilepsy, and others have been able to quantify this progression over time. However, others have failed to demonstrate progression possibly due to the heterogeneity of individuals evaluated. Currently, temporal lobe epilepsy associated with hippocampal sclerosis is regarded as a progressive disorder. Conversely, for other types of epilepsy, the evidence is not so clear. The causes of this damage progression are also unknown although there is consistent evidence that seizure is one of the mechanisms. The conflicting data about epilepsy progression can be a challenge for clinical decisions for an individual patient. Studies with homogenous groups and longer follow-up are necessary for appropriate conclusions about the real burden of damage progression in epilepsies, and neuroimaging will be essential in this context. This article is part of a Special Issue entitled ``The Future of Translational Epilepsy Research{''}. (C) 2012 Elsevier Inc. All rights reserved. (AU)

• Processo FAPESP: 05/56578-4 - Centro multimodal de neuroimagens para estudos em epilepsia
• Beneficiário: Fernando Cendes
• Modalidade de apoio: Auxílio à Pesquisa - Programa CINAPCE - Temático
• Processo FAPESP: 09/54552-9 - Estudo da progressão de dano na epilepsia de lobo temporal mesial com ou sem sinais de esclerose hipocampal
• Beneficiário: Ana Carolina Coan
• Modalidade de apoio: Bolsas no Brasil - Doutorado