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(Reference retrieved automatically from Web of Science through information on FAPESP grant and its corresponding number as mentioned in the publication by the authors.)

Epilepsy as progressive disorders: What is the evidence that can guide our clinical decisions and how can neuroimaging help?

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Coan, Ana C. [1] ; Cendes, Fernando [1]
Total Authors: 2
[1] Univ Estadual Campinas, Neuroimaging Lab, Dept Neurol, BR-13083970 Campinas, SP - Brazil
Total Affiliations: 1
Document type: Review article
Source: Epilepsy & Behavior; v. 26, n. 3, p. 313-321, MAR 2013.
Web of Science Citations: 13

There is evidence that some types of epilepsy progress over time, and an important part of this knowledge has derived from neuroimaging studies. Different authors have demonstrated structural damage more pronounced in individuals with a longer duration of epilepsy, and others have been able to quantify this progression over time. However, others have failed to demonstrate progression possibly due to the heterogeneity of individuals evaluated. Currently, temporal lobe epilepsy associated with hippocampal sclerosis is regarded as a progressive disorder. Conversely, for other types of epilepsy, the evidence is not so clear. The causes of this damage progression are also unknown although there is consistent evidence that seizure is one of the mechanisms. The conflicting data about epilepsy progression can be a challenge for clinical decisions for an individual patient. Studies with homogenous groups and longer follow-up are necessary for appropriate conclusions about the real burden of damage progression in epilepsies, and neuroimaging will be essential in this context. This article is part of a Special Issue entitled ``The Future of Translational Epilepsy Research{''}. (C) 2012 Elsevier Inc. All rights reserved. (AU)

FAPESP's process: 05/56578-4 - Multimodal neuroimaging center for studies in epilepsy
Grantee:Fernando Cendes
Support type: Inter-institutional Cooperation in Support of Brain Research (CINAPCE) - Thematic Grants