Altered CD16 expression on vaginal neutrophils from women with vaginitis

Autor(es)

Beghini, Joziani ^{[1, 2]} ; Giraldo, Paulo C. ^{[1, 2]} ; Riboldi, Ruth ^[1] ; Amaral, Rose L. G. ^[1] ; Eleuterio, Jr., Jose ^[3] ; Witkin, Steven S. ^[4] ; Guimaraes, Fernando ^[1]

Afiliação do(s) autor(es)

^[1] Univ Estadual Campinas, Ctr Atencao Integral Saude Mulher, Hosp Mulher Prof Dr Jose Aristodemo Pinotti, Campinas - Brazil

^[2] Univ Estadual Campinas, Fac Ciencias Med, Dept Tocoginecol, Campinas - Brazil

^[3] Univ Fed Ceara, Fac Med, Dept Saude Maternoinfantil, Fortaleza, Ceara - Brazil

^[4] Cornell Univ, Weill Med Coll, Dept Obstet & Gynecol, Ithaca, NY 14853 - USA

• Tipo de documento: Artigo Científico
• Fonte: EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY; v. 167, n. 1, p. 96-99, MAR 2013.
• Citações Web of Science: 3

Resumo

Objective: Reduced CD16 expression is associated with neutrophil apoptosis. This study aimed to compare CD16 expression on neutrophils in the vagina from women with normal bacterial flora and with vaginitis. Study design: Vaginal lavages were sampled from volunteers diagnosed with bacterial vaginosis (BV, n = 34), vulvovaginal candidiasis (VC, is = 43), BV plus VC (BV + VC, n = 14), and normal flora (NF, n = 51). Neutrophils were identified by expression of CD15, CD16 and CD24 surface markers as assessed by flow cytometry. Results: CD16 expression was elevated in neutrophils from women with vaginitis (BV p < 0.0001; VC p = 0.01; BV + VC p = 0.0027) as compared to women with NF. Conclusion: The reduction in CD16 down-regulation is consistent with prolonged neutrophil viability and activity in the vagina of women with vaginitis. This may contribute to greater microbial clearance and, conversely, with inflammation-associated pathology. (C) 2012 Elsevier Ireland Ltd. All rights reserved. (AU)

• Processo FAPESP: 08/09853-8 - Quantificação das populações de leucócitos presentes no conteúdo vaginal de mulheres com e sem vulvovaginites
• Beneficiário: Paulo César Giraldo
• Modalidade de apoio: Auxílio à Pesquisa - Regular
• Processo FAPESP: 10/05767-0 - Quantificação das populações de leucócitos presentes no conteúdo vaginal de mulheres com e sem vulvovaginites
• Beneficiário: Ruth Riboldi Jordão da Silva Vargas
• Modalidade de apoio: Bolsas no Brasil - Programa Capacitação - Treinamento Técnico