| Full text | |
| Author(s): |
Beghini, Joziani
[1, 2]
;
Giraldo, Paulo C.
[1, 2]
;
Riboldi, Ruth
[1]
;
Amaral, Rose L. G.
[1]
;
Eleuterio, Jr., Jose
[3]
;
Witkin, Steven S.
[4]
;
Guimaraes, Fernando
[1]
Total Authors: 7
|
| Affiliation: | [1] Univ Estadual Campinas, Ctr Atencao Integral Saude Mulher, Hosp Mulher Prof Dr Jose Aristodemo Pinotti, Campinas - Brazil
[2] Univ Estadual Campinas, Fac Ciencias Med, Dept Tocoginecol, Campinas - Brazil
[3] Univ Fed Ceara, Fac Med, Dept Saude Maternoinfantil, Fortaleza, Ceara - Brazil
[4] Cornell Univ, Weill Med Coll, Dept Obstet & Gynecol, Ithaca, NY 14853 - USA
Total Affiliations: 4
|
| Document type: | Journal article |
| Source: | EUROPEAN JOURNAL OF OBSTETRICS & GYNECOLOGY AND REPRODUCTIVE BIOLOGY; v. 167, n. 1, p. 96-99, MAR 2013. |
| Web of Science Citations: | 3 |
| Abstract | |
Objective: Reduced CD16 expression is associated with neutrophil apoptosis. This study aimed to compare CD16 expression on neutrophils in the vagina from women with normal bacterial flora and with vaginitis. Study design: Vaginal lavages were sampled from volunteers diagnosed with bacterial vaginosis (BV, n = 34), vulvovaginal candidiasis (VC, is = 43), BV plus VC (BV + VC, n = 14), and normal flora (NF, n = 51). Neutrophils were identified by expression of CD15, CD16 and CD24 surface markers as assessed by flow cytometry. Results: CD16 expression was elevated in neutrophils from women with vaginitis (BV p < 0.0001; VC p = 0.01; BV + VC p = 0.0027) as compared to women with NF. Conclusion: The reduction in CD16 down-regulation is consistent with prolonged neutrophil viability and activity in the vagina of women with vaginitis. This may contribute to greater microbial clearance and, conversely, with inflammation-associated pathology. (C) 2012 Elsevier Ireland Ltd. All rights reserved. (AU) | |
| FAPESP's process: | 08/09853-8 - Leucocyte shedding to the vaginal content in women with and without vulvovaginitis |
| Grantee: | Paulo César Giraldo |
| Support Opportunities: | Regular Research Grants |