Topical anti-inflammatory activity of yacon leaf extracts

Autor(es)

Rejane B. Oliveira ^[1] ; Daniela A. Chagas-Paula ^[1] ; Adriana Secatto ^[1] ; Thaís H. Gasparoto ^[4] ; Lúcia H. Faccioli ^[5] ; Ana P. Campanelli ^[4] ; Fernando B. Da Costa ^[1]

Afiliação do(s) autor(es)

^[1] Univ Sao Paulo, Fac Ciencias Farmaceut Ribeirao Preto, BR-14040903 Ribeirao Preto, SP - Brazil

^[2] Universidade de São Paulo. Faculdade de Odontologia de Bauru - Brasil

^[3] Universidade de São Paulo. Faculdade de Ciências Farmacêuticas de Ribeirão Preto - Brasil

^[4] Univ Sao Paulo, Fac Odontol Bauru, Bauru, SP - Brazil

• Tipo de documento: Artigo Científico
• Fonte: REVISTA BRASILEIRA DE FARMACOGNOSIA-BRAZILIAN JOURNAL OF PHARMACOGNOSY; v. 23, n. 3, p. 497-505, 2013-05-10.

Resumo

Smallanthus sonchifolius (Poepp.) H. Rob. , Asteraceae, known as yacon, is an herb that is traditionally used for the treatment of diabetes in folk medicine. However, recent studies have demonstrated that this plant has other interesting properties such as anti-microbial and anti-inflammatory actions. Thus, the purpose of this study was to evaluate the topical anti-inflammatory property of different extracts prepared from yacon leaves and analyze the role of different chemical classes in this activity. Three yacon leaf extracts were obtained: aqueous extract, where chlorogenic acid derivatives and sesquiterpene lactones were detected; leaf rinse extract, rich in sesquiterpene lactones; and polar extract, rich in chlorogenic acid derivatives. All the extracts exhibited anti-edematogenic activity in vivo (aqueous extract: 25.9% edema inhibition at 0.50 mg/ear; polar extract: 42.7% inhibition at 0.25 mg/ear; and leaf rinse extract: 44.1% inhibition at 0.25 mg/ear). The leaf rinse extract furnished the best results regarding neutrophil migration inhibition, and NO, TNF-α and PGE2 inhibition. These data indicate that both sesquiterpene lactones and chlorogenic acid derivatives contribute to the anti-inflammatory action, although sesquiterpene lactones seem to have more pronounced effects. In conclusion, yacon leaf extracts, particularly the sesquiterpene lactone-rich extract, has potential use as topical anti-inflammatory agent. (AU)

• Processo FAPESP: 07/00844-3 - Atividades antidiabética, antiinflamatória e toxicologia de yacon (Smallanthus sonchifolius, Asteraceae)
• Beneficiário: Rejane Barbosa de Oliveira
• Modalidade de apoio: Bolsas no Brasil - Doutorado